Abstract:Benzodiazepine (BDZ) misuse is a growing health problem, with 1–2% of patients under BDZ treatment meeting the criteria for use disorder or dependence. Although BDZ addiction potential has been known for decades, much remains unknown its effects on brain functions. The aim of this study was to assess the neuropsychological and neurophysiological profile of a group of chronic insomniacs taking long-term high doses of benzodiazepine. We recruited 17 consecutive patients admitted to our third-level Sleep Medicine… Show more
“…The results seemed to support the evidence for several cognitive models of insomnia, with a potential utility for the clinical assessment of insomnia. In a similar way, Castelnovo et al [3] present the neuropsychological and neurophysiological assessment of a group of chronic insomniacs and long-term, high-dosage benzodiazepine (BDZ) treatment. This cross-sectional study revealed a specific frontal dysfunction in their unique sample and should reinforce the vulnerability of the prefrontal cortex due to sleep loss or disturbed sleep.…”
“…The results seemed to support the evidence for several cognitive models of insomnia, with a potential utility for the clinical assessment of insomnia. In a similar way, Castelnovo et al [3] present the neuropsychological and neurophysiological assessment of a group of chronic insomniacs and long-term, high-dosage benzodiazepine (BDZ) treatment. This cross-sectional study revealed a specific frontal dysfunction in their unique sample and should reinforce the vulnerability of the prefrontal cortex due to sleep loss or disturbed sleep.…”
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