Electrophysiological and clinical tests in dry age-related macular degeneration follow-up: differences between mfERG and OCT

González-García, Emilio; Vilela, Concepción; Arnal, Emma; Muriach, Marí­a; Romero, Francisco J.

doi:10.1007/s10633-016-9545-y

Cited by 12 publications

(10 citation statements)

References 29 publications

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“…Although not routinely used as a tool for AMD diagnosis, electroretinography can be useful to detect retinal dysfunctions arising from retinal diseases, including AMD ( Justilien et al, 2007 ). In fact, some reports show a decreased ERG response in patients with AMD ( González-García et al, 2016 ; Yang et al, 2016 ). The ERG a-wave is classically considered an index of PR activity, whereas the b-wave seems to reflect bipolar and Müller cell function, and OPs, whose origins are less clear, are thought to originate from feedback neural pathways in the inner retina, especially around the inner plexiform layer (IPL) and mainly from amacrine cells.…”

Section: Discussionmentioning

confidence: 99%

Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice

Dieguez

Romeo

Fleitas

et al. 2018

Disease Models &Amp; Mechanisms

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Non-exudative age-related macular degeneration, a prevalent cause of blindness, is a progressive and degenerative disease characterized by alterations in Bruch's membrane, retinal pigment epithelium, and photoreceptors exclusively localized in the macula. Although experimental murine models exist, the vast majority take a long time to develop retinal alterations and, in general, these alterations are ubiquitous, with many resulting from non-eye-specific genetic manipulations; additionally, most do not always reproduce the hallmarks of human age-related macular degeneration. Choroid vessels receive sympathetic innervation from the superior cervical ganglion, which, together with the parasympathetic system, regulates blood flow into the choroid. Choroid blood flow changes have been involved in age-related macular degeneration development and progression. At present, no experimental models take this factor into account. The aim of this work was to analyze the effect of superior cervical gangliectomy (also known as ganglionectomy) on the choroid, Bruch's membrane, retinal pigment epithelium and retina. Adult male C57BL/6J mice underwent unilateral superior cervical gangliectomy and a contralateral sham procedure. Although superior cervical gangliectomy induced ubiquitous choroid and choriocapillaris changes, it induced Bruch's membrane thickening, loss of retinal pigment epithelium melanin content and retinoid isomerohydrolase, the appearance of drusen-like deposits, and retinal pigment epithelium and photoreceptor atrophy, exclusively localized in the temporal side. Moreover, superior cervical gangliectomy provoked a localized increase in retinal pigment epithelium and photoreceptor apoptosis, and a decline in photoreceptor electroretinographic function. Therefore, superior cervical gangliectomy recapitulated the main features of human non-exudative age-related macular degeneration, and could become a new experimental model of dry age-related macular degeneration, and a useful platform for developing new therapies.

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Section: Discussionmentioning

confidence: 99%

Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice

Dieguez

Romeo

Fleitas

et al. 2018

Disease Models &Amp; Mechanisms

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“…Although the literature reported several evidences of photoreceptors and bipolar cells’ dysfunction and of chorioretinal ultrastructural impairment in iAMD, very few and not completely exhaustive information are available on the relationship between macular functional and morphological changes in iAMD. 15 , 36 , 37 …”

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confidence: 99%

“…28 By recording bioelectrical responses from selective retinal areas enclosed between 0°and 20°from the fovea, 29,30 early dysfunction of the foveal, and the parafoveal preganglionic elements has been found at this stage. 15,[29][30][31][32][33][34][35][36][37][38][39] Regarding the macular morphology, several studies performed by using spectral domain-optical coherence tomography (SD-OCT), described that in the initial stages of AMD the peculiar anatomic retinal findings, consisting of drusen and reticular pseudodrusen (also known as subretinal drusenoid deposits [SDD]) are associated with morphological changes of the outer retinal layers (ORLs) 13 with variable degrees of inner retinal layer (IRL) thinning. [9][10][11][12] The advent of the enhanced depth image (EDI)-OCT and of the OCT-angiography (OCTA) allowed us to better explore the involvement of the choroid in initial AMD.…”

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confidence: 99%

Macular Functional and Morphological Changes in Intermediate Age-Related Maculopathy

Parisi

Ziccardi

Costanzo

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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Purpose The purpose of this study was to evaluate macular preganglionic function and to verify its relationship with retinal and choroidal morphology in patients with intermediate age-related macular degeneration (iAMD) patients. Methods All included patients performed multifocal electroretinogram (mfERG) for investigating on macular function from the central 15° of foveal eccentricity, spectral domain optical coherence tomography (SD-OCT) for studying retinal structure, enhanced depth imaging OCT (EDI-OCT) for the measure of choroidal vascularity index (CVI), and OCT-angiography (OCTA) for the evaluation of vessel density (VD) in the superficial and deep capillary plexus, and choriocapillaris (CC) layer. Results Twenty-seven patients with iAMD and 20 age-matched control eyes were analyzed. Significantly ( P < 0.01) delayed and reduced mfERG responses in the central 0 to 2.5°, paracentral 2.5 to 5°, and overall 0 to 5° areas, as well as increased CVI values in both foveal (1 mm centered to the fovea) and fovea + parafovea areas (3 mm centered to the fovea), increased foveal and parafoveal (annular area of 1–3 mm centered to the fovea) retinal pigment epithelium thickness, and volume and parafoveal outer retinal volume were found in iAMD eyes as compared to controls. Moreover, iAMD eyes showed significantly ( P < 0.01) reduced foveal and parafoveal OCTA-VD values in the CC layer when compared to controls. In the iAMD group, not significant ( P > 0.01) correlations were found between morphological and functional parameters. Conclusions Our findings support a dysfunction of photoreceptors and bipolar cells in both foveal and parafoveal areas in the presence of outer retina, CC, and choroidal structural changes, however, not significantly correlated. The observed enlargement of luminal choroidal area (measured by CVI) is possibly compensatory to CC vascular insufficiency.

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“…Traditional analysis of mfERG recordings is based on obtaining the amplitudes and latencies of these waves, and has been shown to be effective in diagnosing glaucoma [13] or age-related macular degeneration [14], among other diseases.…”

Section: Introductionmentioning

confidence: 99%

Empirical Mode Decomposition-Based Filter Applied to Multifocal Electroretinograms in Multiple Sclerosis Diagnosis

Santiago

Castillo

García‐Martín

et al. 2019

Sensors

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As multiple sclerosis (MS) usually affects the visual pathway, visual electrophysiological tests can be used to diagnose it. The objective of this paper is to research methods for processing multifocal electroretinogram (mfERG) recordings to improve the capacity to diagnose MS. MfERG recordings from 15 early-stage MS patients without a history of optic neuritis and from 6 control subjects were examined. A normative database was built from the control subject signals. The mfERG recordings were filtered using empirical mode decomposition (EMD). The correlation with the signals in a normative database was used as the classification feature. Using EMD-based filtering and performance correlation, the mean area under the curve (AUC) value was 0.90. The greatest discriminant capacity was obtained in ring 4 and in the inferior nasal quadrant (AUC values of 0.96 and 0.94, respectively). Our results suggest that the combination of filtering mfERG recordings using EMD and calculating the correlation with a normative database would make mfERG waveform analysis applicable to assessment of multiple sclerosis in early-stage patients. Author Contributions: Conceptualization, E.G.-M., M.J.R., E.M.S.M., and L.B.; methodology, L.d.S., M.O.d.C., C.C., J.M.M., A.L., and B.C.; software, L.d.S., M.O.d.C., C.C., J.M.M., and A.L.; validation, L.d.S., M.O.d.C., C.C., J.M.M., and A.L.; formal Analysis, M.O.d.C. and J.M.M.; investigation, E.G.-M., M.J.R., E.M.S.M., and L.B.; resources, L.B. and E.G.-M.; data Curation, L.d.S., M.O.d.C., C.C., J.M.M., A.L., and B.C.; writing-original draft preparation, L.B., E.G.-M., and M.J.R.; writing-review and editing, L.B., E.G.-M., and M.J.R.; visualization, L.B. and E.G.-M.; supervision, L.B. and E.G.-M.; project administration, L.B. and E.G.-M.; funding acquisition, L.B. and E.G.-M. All authors have read and agreed to the published version of the manuscript.

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Electrophysiological and clinical tests in dry age-related macular degeneration follow-up: differences between mfERG and OCT

Abstract: OCT and mfERG are useful in the diagnosis and monitoring of dry AMD patients, whilst mfERG is the most sensitive technique to study the progression of this disease in short periods of time.

Cited by 12 publications

References 29 publications

Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice

Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice

Macular Functional and Morphological Changes in Intermediate Age-Related Maculopathy

Empirical Mode Decomposition-Based Filter Applied to Multifocal Electroretinograms in Multiple Sclerosis Diagnosis

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