Electrophoretic Studies of the Prower Factor; a Blood Coagulation Factor which differs from Factor VII

The Coagulant Action of Russell's Viper Venom; The Use of Antivenom in Defining its Reaction with a Serum Factor

“…It is likely that Factor X is required for thc clotting of whole blood by venom, because the 'Stypven' clotting time is long in blood from cases of the Stuart-Prower dcfcct (Hougic, 1956;Denson, 1958). If, as is suggested here, the venom reacts specifically with Factor X, then the conversion ofplasnia Factor X into an active product is probably the first stage in the coagulant action of the venom.…”

Six Characters in Search of An Author: The History of the Nomenclature of Coagulation Factors

“…Factor X was discovered by the study of two patients with a congenital bleeding tendency. Miss Audrey Prower (Fig 4) was 22‐year‐old when she was admitted to University College Hospital in London in 1956 for investigation of a bleeding tendency prior to a dental extraction (Telfer et al , 1956; Denson, 1957). She had a significant past medical history, including significant bleeding after two previous dental extractions in 1939 and 1945.…”

Congenital factor X deficiency in Japan.

“…Genetically, it is also thought to be transferred as an autosomal recessive. Denson (1958) made a cross-matching test of the plasma from cases of Prower defect and Stuart defect and found no correction, leading them to conclude that they are due to the same factor defect. Furthermore, they maintain that the report of Telfer et al (1956) using RVV (which came to contradictory conclusions) is incorrect due to the technical errors.…”