Electrophoretic Serum Protein Patterns in the Aged†

Karel, J; Wilder, Violet M.; Beber, Meyer

doi:10.1111/j.1532-5415.1956.tb00850.x

Cited by 15 publications

(1 citation statement)

References 30 publications

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“…These values emphasize that, under conditions of disease, there is a quantitative change in protein concentration. Karel et al (14) and Das and Bhattacharya (3) found that serum globulin values increased and albumin values decreased with age, both relatively and absolutely. As shown in Table , the following changes were observed in our series when health states were compared: 1) an elevation with age in both percentile and absolute concentrations of gamma globulin; 2) an increase with age in the percentage of beta globulin, reflected in a less pronounced elevation in absolute concentration; 3) a relative increase with age in the alpha globulin fraction, but a decrease in absolute concentration; and 4) a marked decrease in both relative and absolute concentrations of albumin in the aged subjects.…”

Section: Discussionmentioning

confidence: 99%

Effects of Aging on Granulopoietic Activity (Colony‐Stimulating Factor)

Earney

Graham

1975

J American Geriatrics Society

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This investigation was undertaken to determine whether there is a decrease of granulopoietic activity in subjects of the geriatric age group. Colony-stimulating factor (CSF) is an alpha glycoprotein which causes proliferation of granulocytes in vitro. A study was made of the variation in the level of CSF with age and the state of health in 78 subjects. They were classified into two groups-young (ages 22-60) and old (ages 70-94). The state of health was classified as normal, acute disease, or chronic disease. The results showed that serum CSF does vary with age and health. The CSF levels were higher in the young than in the old. For both age groups, the CSF levels were elevated in acute disease, and subnormal in chronic disease.

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Section: Discussionmentioning

confidence: 99%