Electroorganic Synthesis and the Construction of Addressable Molecular Surfaces

Abstract

In this Minireview, an electroorganic synthesis approach to the construction of addressable, complex molecular surfaces is described along with the parameters that guided the development of that synthetic approach. The result of the work is a synthetic toolbox that will allow microelectrode arrays to be used for the “real‐time” monitoring of small molecule interactions with biological targets.

Capitalizing on Mediated Electrolyses for the Construction of Complex, Addressable Molecular Surfaces

“…Those electrodes are coated with a porous polymer that renders direct electrolyses impossible, but as highlighted frequently in this special issue, electrodes are powerful tools when it comes to making and recycling chemical reagents and catalysts. With that conclusion, our group’s reluctance to delve into indirect electrochemical reactions evaporated. , …”

“…The exact opposite approach could be used to conduct basic reactions at selected electrodes in an array. We figured that if such an approach worked for acid and base, then a similar strategy might work for the confinement of a wide variety of catalysts and reagents. , One just needed something in the solution above the array to destroy whatever reagent or catalyst was generated.…”

“…With that conclusion, our group's reluctance to delve into indirect electrochemical reactions evaporated. 69,70 ■ MEDIATED ELECTROCHEMISTRY. A PRIMER In recent years, indirect or mediated electrochemical reactions have been dominating the development of new electroorganic synthetic methods.…”

From Molecules to Molecular Surfaces. Exploiting the Interplay Between Organic Synthesis and Electrochemistry

“…It was against this backdrop that we became aware of microelectrode arrays and their potential as bioanalytical tools. − In particular, we were interested in the experiment highlighted in Figure . In this experiment, a molecular library is synthesized on a microelectrode array so that each member of the library is next to a unique, addressable electrode or set of electrodes in the array.…”

Microelectrode Arrays, Dihydroxylation, and the Development of an Orthogonal Safety-Catch Linker

“…Because they can serve as tools for evaluating biological interactions in real time, , we have been developing the synthetic chemistry needed to place the members of a molecular library by any electrode or combination of electrodes in a microelectrode array . For each method developed, the transformation uses the selected electrode or electrodes to generate the required catalyst or reagent.…”