Electrons as a Reagent in Solid‐Phase Organic Synthesis

Abstract

Solid-Phase Organic Synthesis (SPOS) has become an important tool for the high-throughput synthesis of bioactive molecules or new catalysts. The main advantage of this approach is the covalent attachment of the substrate to an insoluble support, enabling reaction workup through simple filtration. However, the heterogeneous nature of SPOS imposes limitations on the organic reactions applicable on solid phase. Electron-transfer reactions and electroorganic synthesis are reaction types that have not yet received much attention in this context. In this review the current status of electrontransfer reactions carried out on solid phase is described and future developments are discussed. Abbreviations

CHAPTER 8. A Chromatography-free Method for the Isolation of Products from Mechanochemical Reactions

“…[20][21][22] In principle this is a very clean and simple method for the isolation of compounds. Unfortunately, to use polymer supported resins, the resin needs to be activated in a solvent that allows the polymer to swell.…”

Brønsted Acid Mediated Alkenylation and Copper-Catalyzed Aerobic Oxidative Ring Expansion/Intramolecular Electrophilic Substitution of Indoles with Propargyl Alcohols: A Novel One-Pot Approach to Cyclopenta[c]quinolines

“…For this reason, the synthesis and reactivity of indoles is currently a prime area of research activity. , An important feature of this system is that the C–H bonds at C-2 and C-3 can be readily functionalized . Utilizing this feature, there are only a handful of reports regarding the ring-expansion reactions of indoles . The first example of cyclopentadienyl fused tetra­hydro­quinoline derivatives through a palladium-catalyzed ring-expansion reaction of indoles with alkynes has been reported recently by Jiao and co-workers .…”