Electronic transport in a graphene single layer: application in amino acid sensing

Abstract

We modeled a type of field-effect transistor device based on graphene for the recognition of amino acids with a potential application in the building of a protein sequencer.

Detection of some amino acids with modulation-doped and surface-nanoengineered GaAs Schottky P-I-N diodes

“…We note the asymmetry of I-V curves upon bias voltage inversion offers useful information, similar to studies reported in 24,27 . Essentially, analysis of either I-V curves or differential conductance (here, both), points towards energy levels where main conduction channels occur.…”

“…The Hamiltonian in MLWF describing the quantum conductance is then solved by constructing the left and the right leads. The method details mirror the efforts in reference 20 , and related references [21][22][23][24] . We caution that we are using a simplified model system in the form of Bias Lead -GaAs -Bias Lead and a single amino acid molecule, instead of a more realistic AlGaAs-GaAs-AlGaAs N-I-P system with a larger number of atoms and with a water solution of amino acid.…”

Individual Identification of Amino Acids on an Atomically Thin Hydrogen Boride System Using Electronic Transport Calculations

“…Studying proteins at the molecular level is of particular importance as it provides insight into molecular mechanisms and gives the opportunities to develop new protein-based molecular diagnostic tools for research and clinical applications. Single-molecule protein sequencing would be very significant in proteomic research with important biomedical impacts. , …”

“…Since 2D nanomaterials are promising for applications in a wide range of fields due to their unique structural, electronic, and transport properties, they offer an excellent possibility for nanoelectronics-based applications too. Therefore, 2D material-based nanoscale devices are actively being investigated for single-molecule bioelectronics. − Graphene as a biomolecule sensor has attracted considerable attention since it provides various sensing mechanisms such as charge transfer, charge scattering, and π–π stacking interactions . Furthermore, it is a zero-gap semiconductor capable of significantly upgrading the selectivity and sensitivity of field-effect transistor (FET) biosensors on the road to more efficient enzymatic biomolecule sensing − and DNA sequencing. , In particular, the interactions between amino acids and graphene have been extensively investigated by both experimentalists and theoreticians. ,,,,,,, However, the significantly low ON/OFF current ratio limits the use of graphene in bioelectronic device applications.…”

A theoretical study of allopurinol drug sensing by carbon and boron nitride nanostructures: DFT, QTAIM, RDG, NBO and PCM insights

“… 26–28 Similarly, S. J. Rodríguez and E. A. Albanesi proposed a type of field-effect transistor device based on graphene for detecting amino acids with the help of DFT calculations in combination with the non-equilibrium Green's function in the OpenMX3.844 software package. 29 In addition, M. Z. Tonel et al conducted a theoretical study and they found physisorption interaction between a pristine graphene nanosheet and doxorubicin anticancer drug with 0.49 eV binding energy and also showed a decrease in the interaction with increasing temperature by means of DFT theory with the GGA-PBE functional in SIESTA code. 30 Moreover, the C 24 nanocage has been proposed as a sensing nanostructure towards anticancer drug Melphalan by performing DFT at the B3LYP/6-31G(d) level of theory by the research group of E. S. Mirkamali et al 31 Finally, E. O. Kweitsu's research group theoretically showed that pristine C 60 is a suitable sensor for sensing phosgene gas by using DFT/LDA calculation in Quantum Espresso Software.…”