Electronic to ionic transduction of the electric field applied to PEDOT:PSS substrates to the cell cultures on top

Morgado, Jorge; Sordini, Laura; Ferreira, Frederico Castelo

doi:10.1016/j.bioelechem.2022.108099

Cited by 2 publications

(2 citation statements)

References 41 publications

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“…In most of the studies reviewed here, such screening is mostly overlooked in favor of the maximization of electroconductivity. It is arguable that the mechanism of transduction of ES into a biological response is solely dependent on the electron or ionic conductivity of an electroconductive polymers [ 144 , 145 ], thus potentially making this a non-issue. However, the natural de-doping of PANI:CSA that occurs in aqueous solutions [ 38 , 106 ] limits the reliability and applicability of PANI:CSA-based platforms for the long-term ES of neural cells (e.g., 28 days).…”

Section: Challenges Opportunities and Conclusionmentioning

confidence: 99%

Designing Electrical Stimulation Platforms for Neural Cell Cultivation Using Poly(aniline): Camphorsulfonic Acid

et al. 2023

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Electrical stimulation is a powerful strategy to improve the differentiation of neural stem cells into neurons. Such an approach can be implemented, in association with biomaterials and nanotechnology, for the development of new therapies for neurological diseases, including direct cell transplantation and the development of platforms for drug screening and disease progression evaluation. Poly(aniline):camphorsulfonic acid (PANI:CSA) is one of the most well-studied electroconductive polymers, capable of directing an externally applied electrical field to neural cells in culture. There are several examples in the literature on the development of PANI:CSA-based scaffolds and platforms for electrical stimulation, but no review has examined the fundamentals and physico-chemical determinants of PANI:CSA for the design of platforms for electrical stimulation. This review evaluates the current literature regarding the application of electrical stimulation to neural cells, specifically reviewing: (1) the fundamentals of bioelectricity and electrical stimulation; (2) the use of PANI:CSA-based systems for electrical stimulation of cell cultures; and (3) the development of scaffolds and setups to support the electrical stimulation of cells. Throughout this work, we critically evaluate the revised literature and provide a steppingstone for the clinical application of the electrical stimulation of cells using electroconductive PANI:CSA platforms/scaffolds.

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Section: Challenges Opportunities and Conclusionmentioning

confidence: 99%

Designing Electrical Stimulation Platforms for Neural Cell Cultivation Using Poly(aniline): Camphorsulfonic Acid

et al. 2023

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“…Its operating principle is still under study. The most recent hypothesis point out to the ionic perturbation of the electric double layer (Morgado et al [373]). In the present section, we will discuss the different techniques and their effects and functional parameters.…”

Section: Electrostimulation On Neural Precursor Cells (Npcs) With Con...mentioning

confidence: 99%

Electronic devices for the combination of electrically controlled drug release, electrostimulation, and optogenetic stimulation for nerve tissue regeneration

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Es difícil de expresar con palabras el profundo agradecimiento que quisiera transmitir a todas las personas que me han servido de inspiración, guía, y apoyo durante estos cuatro años y medio de estudios de doctorado.En primer lugar, quiero agradecer a mis directores, Prof. Miguel Alcañiz y Prof. Ramón Martínez, por ofrecerme la oportunidad de desarrollar este trabajo doctoral, y su guía y orientación en el proceso, en el que el resultado no sólo es el presente documento, si no mi formación como investigador.Gracias a mis colegas del Grupo en Desarrollo Electrónico y Sensores Impresos (ged+ps IDM

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Electronic to ionic transduction of the electric field applied to PEDOT:PSS substrates to the cell cultures on top

Cited by 2 publications

References 41 publications

Designing Electrical Stimulation Platforms for Neural Cell Cultivation Using Poly(aniline): Camphorsulfonic Acid

Designing Electrical Stimulation Platforms for Neural Cell Cultivation Using Poly(aniline): Camphorsulfonic Acid

Electronic devices for the combination of electrically controlled drug release, electrostimulation, and optogenetic stimulation for nerve tissue regeneration

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