Electronic signature of DNA bases via Z-shaped graphene nanoribbon with a nanopore

Wasfi, Asma; Awwad, Falah; Ayesh, Ahmad I.

doi:10.1016/j.biosx.2019.100011

Cited by 12 publications

(15 citation statements)

References 44 publications

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“…Underneath the channel, a gate made of metal is added in order to have a three terminal device which is eventually a FET device. The gate is supplied with 2 V. Figure 11 reveals that the resulting currents are at the microamperes level which indicates much better sensitivity compared to the previous published paper [36].…”

Section: Transmission Spectrummentioning

confidence: 78%

“…DNA bases affect the nano pore charge density within the surrounding area leading to unique current. The current is multiple orders of magnitude greater than the transverse current utilized in previous sensors [36,49]. Figure 13 displays the current signature for each DNA base for bare sensor and with gold or silver nanoparticles.…”

Section: Currentmentioning

confidence: 94%

“…Theoretical studies to enhance the current across nano gaps [47,51] or nano pores [16,36,52] offer moderate improvement. Moreover, applying high bias to obtain high current signal may lead DNA backbone attraction, or breakdown the sensor at high electric field.…”

Section: Comparative Analysismentioning

confidence: 99%

“…Moreover, applying high bias to obtain high current signal may lead DNA backbone attraction, or breakdown the sensor at high electric field. Unlike other recent sensors based on transverse electronic properties which use small current across a nano pore or a nano gap resulting in low signal, the present device enhances electrical current results from nano ampere to microampere [36] thus makes it easier to detect, measure, and read. Placing a DNA base within the pore affects the charge density resulting in a unique current for each base.…”

Section: Comparative Analysismentioning

confidence: 99%

“…The electrical signatures of DNA bases change with their orientation and translation. The aim of this study is to improve the sensor sensitivity by adding a gate terminal to the z-shaped graphene nano ribbon introduced in previous work [36]. Furthermore, the effect of graphene decoration with silver and gold nanoparticles and interaction between graphene and the nanoparticles on electronic structure are examined.…”

Section: Introductionmentioning

confidence: 99%

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DNA sequencing via Z-shaped graphene nano ribbon field effect transistor decorated with nanoparticles using first-principle transport simulations

2020

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DNA detection has revolutionized medical and biological research fields. It provides a wealth of medical information for each individual, which can be used in a personalized medicinal procedure in the future. Genome sequence helps to enhance our perception of inheritance, disease, and individuality. This work aims to improve DNA sequencing accuracy and the overall current signal using a novel nano pore based sensor that is developed to detect and identify the DNA bases. Herein, a novel z-shaped field effect transistor with a nano pore for the aim of DNA detection is studied, where a gate terminal is added below the center of the z-shaped graphene nano ribbon. First-principle transport calculations are used to identify the DNA bases and electronic signature. An efficient density functional theory approach combined with non-equilibrium Green's function formalism (DFT + NEGF) are utilized to detect the transmission spectrum and current for DNA nucleo bases: Adenine, Thymine, Guanine, and Cytosine. Using transmission current, a distinctive electronic signature is generated for each DNA base to detect each DNA sequence. Various orientations and lateral position for each DNA base are considered. Moreover, the effect of decorating the developed DNA sensor with gold and silver nanoparticles on the sensor's electrical current and transmission spectra is studied and analyzed. The results suggest that the z-shaped sensor could achieve DNA sequencing with high accuracy. The practical implementation of this work represents the capability to anticipate and cure diseases from the genetic makeup perspective.

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Section: Transmission Spectrummentioning

confidence: 78%

Section: Currentmentioning

confidence: 94%

Section: Comparative Analysismentioning

confidence: 99%

Section: Comparative Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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DNA sequencing via Z-shaped graphene nano ribbon field effect transistor decorated with nanoparticles using first-principle transport simulations

2020

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Electronic, transport, magnetic, and optical properties of graphene nanoribbons and their optical sensing applications: A comprehensive review

et al. 2022

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Low dimensional materials have attracted great research interest from both theoretical and experimental point of views. These materials exhibit novel physical and chemical properties due to the confinement effect in low dimensions. The experimental observations of graphene open a new platform to study the physical properties of materials restricted to two dimensions. This featured article provides a review on the novel properties of quasi one‐dimensional (1D) material known as graphene nanoribbon. Graphene nanoribbons can be obtained by unzipping carbon nanotubes (CNT) or cutting the graphene sheet. Alternatively, it is also called the finite termination of graphene edges. It gives rise to different edge geometries, namely zigzag and armchair, among others. There are various physical and chemical techniques to realize these materials. Depending on the edge type termination, these are called the zigzag and armchair graphene nanoribbons (ZGNR and AGNR). These edges play an important role in controlling the properties of graphene nanoribbons. The present review article provides an overview of the electronic, transport, optical, and magnetic properties of graphene nanoribbons. However, there are different ways to tune these properties for device applications. Here, some of them, such as external perturbations and chemical modifications, are highlighted. Few applications of graphene nanoribbon have also been briefly discussed.

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Investigation of sensing behavior of carbon nitride (C₆N₈) for detection of phosphine (PH₃) and phosphorous trichloride (PCl₃): A DFT approach

Jamil,

Saleem,

Ahmed

et al. 2024

Int J of Quantum Chemistry

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This study shows the exploration of the gas‐sensing capabilities of C6N8 material against toxic gases like phosphine (PH3) and phosphorous trichloride (PCl3). First‐principles study based on M05‐2X/LanL2DZ (d, p) method was performed to investigate the interaction energy (Eint.), frontier molecular orbitals (FMOs), natural bonding orbital (NBO), noncovalent interactions (NCIs), partial density of states (PDOS), molecular electrostatic potential (MEP), and quantum theory of atoms in molecules (QTAIM) analyses. The interaction energy results showed that PCl3@C6N8 (−23.45 kJ/mol) is more stable than PH3@C6N8 (−14.79 kJ/mol). A considerable decrease in the HOMO‐LUMO band gap of C6N8 was observed as a result of its complexation with the analytes. QTAIM and NCI analyses indicated the presence of weak noncovalent interactions between C6N8 and gases (PH3 and PCl3). SAPT0 analysis was performed to quantify the NCIs. MEP maps of complexes revealed the localization of electronic density on C6N8. The little recovery time of complexes (determined at 300 K) showed that C6N8 can serve as a reusable sensing material against PH3 and PCl3. Our results demonstrate that the C6N8 surface is a reliable material for detecting phosphine and phosphorous trichloride gases.

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Electronic signature of DNA bases via Z-shaped graphene nanoribbon with a nanopore

Cited by 12 publications

References 44 publications

DNA sequencing via Z-shaped graphene nano ribbon field effect transistor decorated with nanoparticles using first-principle transport simulations

DNA sequencing via Z-shaped graphene nano ribbon field effect transistor decorated with nanoparticles using first-principle transport simulations

Electronic, transport, magnetic, and optical properties of graphene nanoribbons and their optical sensing applications: A comprehensive review

Investigation of sensing behavior of carbon nitride (C₆N₈) for detection of phosphine (PH₃) and phosphorous trichloride (PCl₃): A DFT approach

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Electronic signature of DNA bases via Z-shaped graphene nanoribbon with a nanopore

Cited by 12 publications

References 44 publications

DNA sequencing via Z-shaped graphene nano ribbon field effect transistor decorated with nanoparticles using first-principle transport simulations

DNA sequencing via Z-shaped graphene nano ribbon field effect transistor decorated with nanoparticles using first-principle transport simulations

Electronic, transport, magnetic, and optical properties of graphene nanoribbons and their optical sensing applications: A comprehensive review

Investigation of sensing behavior of carbon nitride (C6N8) for detection of phosphine (PH3) and phosphorous trichloride (PCl3): A DFT approach

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Resources

About

Investigation of sensing behavior of carbon nitride (C₆N₈) for detection of phosphine (PH₃) and phosphorous trichloride (PCl₃): A DFT approach