Electronic nose detects heart failure from exhaled breath

Witt, Katharina; Fischer, Claudia; Reulecke, Sina; Kechagias,; Surber, Ralf; Figulla, Hans R.; Voss, Andreas

doi:10.1515/bmt-2013-4145

Cited by 6 publications

(3 citation statements)

References 9 publications

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“…We are not able to compare our results with those of Samara et al [18], because VOCs were analyzed using a selected ion-flow tube mass-spectrometry, while we used an electronic nose, furthermore no data are available on the age of the population of that study. Our data, however, can be compared to those of Witt et al [23], albeit they used an electronic nose based on a metal oxide gas sensor versus our based on QMB sensors. Witt et al found a discrimination rate between controls and patients with heart failure of 91% compared to 81% in our study, however that study had a smaller sample size (13 patients with decompensated heart failure and 13 controls) and did not use a train/test approach.…”

Section: Discussionmentioning

confidence: 95%

Analysis of volatile organic compounds: an innovative approach to heart failure characterization in older patients

et al. 2018

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Section: Discussionmentioning

confidence: 95%

Analysis of volatile organic compounds: an innovative approach to heart failure characterization in older patients

et al. 2018

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“…The processing of the patient measurement protocol (based on a predefined temperature control of the sensor heater optimized in preliminary studies [ 35 ]; see Figure 3 a) is started with a cyclic thermal cleaning of the sensors until the sensor layers reach their original reference resistances (time-variable process). This is followed by the recording of the room air composition and the actual two patient measurements.…”

Section: Methodsmentioning

confidence: 99%

Detection of Liver Dysfunction Using a Wearable Electronic Nose System Based on Semiconductor Metal Oxide Sensors

et al. 2022

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The purpose of this exploratory study was to determine whether liver dysfunction can be generally classified using a wearable electronic nose based on semiconductor metal oxide (MOx) gas sensors, and whether the extent of this dysfunction can be quantified. MOx gas sensors are attractive because of their simplicity, high sensitivity, low cost, and stability. A total of 30 participants were enrolled, 10 of them being healthy controls, 10 with compensated cirrhosis, and 10 with decompensated cirrhosis. We used three sensor modules with a total of nine different MOx layers to detect reducible, easily oxidizable, and highly oxidizable gases. The complex data analysis in the time and non-linear dynamics domains is based on the extraction of 10 features from the sensor time series of the extracted breathing gas measurement cycles. The sensitivity, specificity, and accuracy for distinguishing compensated and decompensated cirrhosis patients from healthy controls was 1.00. Patients with compensated and decompensated cirrhosis could be separated with a sensitivity of 0.90 (correctly classified decompensated cirrhosis), a specificity of 1.00 (correctly classified compensated cirrhosis), and an accuracy of 0.95. Our wearable, non-invasive system provides a promising tool to detect liver dysfunctions on a functional basis. Therefore, it could provide valuable support in preoperative examinations or for initial diagnosis by the general practitioner, as it provides non-invasive, rapid, and cost-effective analysis results.

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“…This method allows differentiating compensated from decompensated heart failure subjects, and healthy individuals, with high accuracy. Further investigations must be done to better evaluate this data [33].…”

Section: Other Compoundsmentioning

confidence: 99%

Exhaled Breath Analysis in Heart Failure

Marcondes‐Braga

Batista

Bacal

et al. 2016

Curr Heart Fail Rep

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Heart failure (HF) is a clinical condition that presents high morbidity and mortality and is one of the main reasons for hospital admissions all over the world. Although biochemical processes that occur in the body during heart failure are known, this syndrome is still associated to poor prognosis. Exhaled breath analysis has emerged as a promising noninvasive tool in different clinical conditions and, recently, it has been also tested in patients with HF. This review presents the main breath HF biomarkers, which reflect metabolic changes that occur in this complex syndrome. It also discusses the diagnostic and prognostic value of exhaled breath compounds for HF and makes a short description of the main technologies involved in this analysis. Some perspectives on the area are presented as well.

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Electronic nose detects heart failure from exhaled breath

Cited by 6 publications

References 9 publications

Analysis of volatile organic compounds: an innovative approach to heart failure characterization in older patients

Analysis of volatile organic compounds: an innovative approach to heart failure characterization in older patients

Detection of Liver Dysfunction Using a Wearable Electronic Nose System Based on Semiconductor Metal Oxide Sensors

Exhaled Breath Analysis in Heart Failure

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