Electronic cigarettes containing nicotine increase thrombotic activity and impair microcirculation

Lyytinen, Gustaf; Bryndal, Amelie; Anesäter, Erik; Antoniewicz, Lukasz; Blomberg, Anders; Wallén, Håkan; Bosson, Jenny A.; Hedman, Linnéa; Mobarrez, Fariborz; Tehrani, Sara; Lundbäck, Magnus

doi:10.1183/13993003.congress-2021.oa2576

Cited by 3 publications

(4 citation statements)

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“…Results from a Swedish randomized control study, presented at the European Respiratory Society Congress September 2021, suggested that aerosolized nicotine from vaping was associated with increased thromboembolic activity and disruption of small vessel dilation and relaxation. 21 …”

Section: Known and Potential Harmsmentioning

confidence: 99%

“…20 Results from a Swedish randomized control study, presented at the European Respiratory Society Congress September 2021, suggested that aerosolized nicotine from vaping was associated with increased thromboembolic activity and disruption of small vessel dilation and relaxation. 21 Earlier studies have shown conflicting evidence about blood pressure and heart rate reactions associated with e-cigarette use, possibly related to the generation of devices used and nicotine concentration. 1 Overall, the consensus is that vaping alone presents less harm to blood pressure and heart rate regulation than use of traditional combustible cigarettes.…”

Section: Known and Potential Harmsmentioning

confidence: 99%

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E-Cigarettes—a review of the evidence—harm versus harm reduction

2022

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The World Health Organization estimates there are 1.1 billion cigarette smokers across the globe and that tobacco related deaths number 7 million per year. Electronic nicotine delivery systems (ENDS) are available to contribute options for smoking cessation and include e-cigarettes, e-hookahs, vape pens, mods, and vaping. The growing use of ENDS, or e-cigarettes, in the US and globally across populations is dramatic. Although users may think that e-cigarettes are less harmful than combustible tobacco products, the evidence shows that there are known risks and harms for users. E-cigarettes have varying amounts of toxicants, nicotine, and carcinogens and put the user at risk for lung diseases and COVID-19 similar to smokers. Currently, most governing bodies have not approved e-cigarettes as a smoking cessation tool but do state if a person has failed conventional smoking cessation treatments that e-cigarettes used alone for the short term may help those to quit combustible tobacco and nicotine. A shared decision-making approach should be used when discussing e-cigarettes as a harm reduction tool. More studies and long-term data are needed to assess potential benefits and harms. What is known is that prevention efforts and policy are needed to avoid adolescents and other vulnerable populations from initiating tobacco or e-cigarette use.

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Section: Known and Potential Harmsmentioning

confidence: 99%

Section: Known and Potential Harmsmentioning

confidence: 99%

E-Cigarettes—a review of the evidence—harm versus harm reduction

2022

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“…L yytinen et al . [ 50 ] found that e-cigarette vapour containing nicotine had an immediate impact on thrombus formation and vascular function. However, e-cigarette use without nicotine did not affect microcirculation or thrombogenicity.…”

Section: Tobacco and Nicotine Research During The Pandemicmentioning

confidence: 99%

“…Contrary to the non-exposure control group, the use of heated tobacco products increased arterial stiffness and thrombus formation in healthy young individuals (n=23). Findings presented by Gustaf Lyytinen revealed that regular e-cigarette or heated tobacco use may impact vascular health [ 50 , 51 ].…”

Section: Tobacco and Nicotine Research During The Pandemicmentioning

confidence: 99%

ERS International Congress 2021: highlights from the Epidemiology and Environment Assembly

et al. 2022

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In this article, early career members of the Epidemiology and Environment Assembly of the European Respiratory Society (ERS) summarise a selection of four sessions from the Society's 2021 virtual congress. The topics covered focus on chronic respiratory disease epidemiology, the health effects of tobacco and nicotine, and the respiratory health impact of environmental exposures and climate change. While the burden of chronic respiratory diseases such as COPD is expected to increase in the next decades, research on modifiable risk factors remains key. The tobacco and nicotine research presented here focuses on recent evolutions in cigarette alternatives, including vaping and the use of heated tobacco products, and changes in behaviours related to the coronavirus disease 2019 pandemic. The 2021 World Health Organization air quality guidelines were also a major topic of the congress. Despite their benefits, challenges remain in driving and implementing environmental health policies to take into account the respiratory effects observed at very low air pollution concentrations, as well as the impact of climate change on environmental exposures.

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