Abstract:The TATA box is a promoter sequence able to interact directly with the components of the basal transcription initiation machinery. We investigate the changes in the electronic and magnetic properties of a TATA-DNA sequence when functionalized with different chemical groups; using the first-principles density functional theory specifically, the TATA-DNA sequences were functionalized with methyl groups (CH 3 , methylation), amino groups (NH 2 , amination), imine groups (NH, imination), chloroamine groups (NCl 2 … Show more
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