Electron transfer engineering of artificially designed cell factory for complete biosynthesis of natural products
Jingwen Zhou,
Qihang Chen,
Wenqian Wei
et al.
Abstract:Biosynthesis of natural products (NPs) by artificially designed cell factories often involves numerous nicotinamide adenine dinucleotide phosphate (NADPH)-dependent enzymes that mediate electron transfer reactions. However, the mechanisms of electron transfer from regeneration to the final delivery to the active centers of various types of NADPH-dependent enzymes remain elusive, limiting our ability to systematically engineer electron transfer (ETE) to improve NPs production. Here, we elucidated the electron t… Show more
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