Electron Temperature Radial Profile Research of Aluminum Wire-Array Z-Pinch

Jian, 鲁建 Lu; Shali, 肖沙里 Xiao; Qingguo, 阳庆国 Yang; Lifeng, 刘利锋 Liu; Yufen, 毋玉芬 Wu

doi:10.3788/cjl201239.0815001

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“…Within this line of research, three different manuscripts have reported metal-free oxidative coupling of alcohols and amines, mediated by strong basic conditions, to give rise to either imine or alkylated amines. 30 31 32 . The synthesis of purine rings from diaminopyrimidines using both aromatic and aliphatic aldehydes and an iron catalyst has also been previously described 33 .…”

Section: Resultsmentioning

confidence: 99%

Amide-controlled, one-pot synthesis of tri-substituted purines generates structural diversity and analogues with trypanocidal activity

Villatoro

Unciti-Broceta

Contreras‐Montoya

et al. 2015

Sci Rep

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A novel one-pot synthesis of tri-substituted purines and the discovery of purine analogues with trypanocidal activity are reported. The reaction is initiated by a metal-free oxidative coupling of primary alkoxides and diaminopyrimidines with Schiff base formation and subsequent annulation in the presence of large N,N-dimethylamides (e.g. N,N-dimethylpropanamide or larger). This synthetic route is in competition with a reaction previously-reported by our group1, allowing the generation of a combinatorial library of tri-substituted purines by the simple modification of the amide and the alkoxide employed. Among the variety of structures generated, two purine analogues displayed trypanocidal activity against the protozoan parasite Trypanosoma brucei with IC50 < 5 μM, being each of those compounds obtained through each of the synthetic pathways.

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Section: Resultsmentioning

confidence: 99%