Electron spin resonance and optical studies of the interaction between NO2 and unsaturated lipid components

Estefan, R.M.; Gause, Emily M.; Rowlands, J. R.

doi:10.1016/0013-9351(70)90060-5

Cited by 16 publications

(2 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From similar observations, Berge (1963) concluded that NO2 causes cellular plasmolysis because of lipid breakdown in membranes. Unsaturated lipids in monolayers readily bind molecules like NO2 (Felmeister, Amarat & Weiner, 1970) and direct peroxidation of fatty acids as a consequence of this attached NO2 has been studied extensively (Estefan, Gause & Rowlands, 1970;Roehm, Hadley & Menzel, 1971 a;Rowland & Gause, 1971;Pryor & Lightsey, 1981). Two types of reactions take place within fatty acids.…”

Section: Membrane Effectsmentioning

confidence: 99%

Tansley Review No. 24 Why are atmospheric oxides of nitrogen usually phytotoxic and not alternative fertilizers?

1990

View full text Add to dashboard Cite

SUMMARY Atmospheric pollution by the oxides of nitrogen, NO and NO2, can cause reductions in growth but rarely visible injury. This review considers their uptake into foliage, as well as their subsequent metabolism and physiology, and attempts to explain why these gases are often phytotoxic. The combined stresses of resisting cellular acidification, enhanced levels of nitrite (and ammonia), and the direct interference of the free radical ('N=O) with critical enzymes, reaction centres and regulatory mechanisms are thought to be the main reasons why oxides of nitrogen, especially NO, inhibit growth. If other air pollutants such as SO2 are also present with NO or NO2 then free radical‐induced injury, similar to that caused by O3 alone, also occurs.

show abstract

Section: Membrane Effectsmentioning

confidence: 99%

Tansley Review No. 24 Why are atmospheric oxides of nitrogen usually phytotoxic and not alternative fertilizers?

1990

View full text Add to dashboard Cite

show abstract

“…The importance of NO x is linked to the fact that they may react with other compounds in the smoke to generate nitrosamines, propenal, hydrazines, amines, urethane and quinoline [11,12]. NO is also known to participate in free radical reactions [13]. In this work our objective was to conduct preliminary study on the adsorption of NO 2 and NO by zeolite in ambient temperature.…”

Section: Introductionmentioning

confidence: 99%

Adsorption of nitrogen oxides by the moisture-saturated zeolites in gas stream

Yang¹,

Zhuang²,

Feng³

et al. 2009

Journal of Hazardous Materials

View full text Add to dashboard Cite

Reaction of Nitrogen Dioxide With Blood and Lung Components

Rowlands¹

1971

Arch Intern Med

View full text Add to dashboard Cite

Electron spin resonance studies of the effects of nitrogen dioxide and cigarette smoke upon blood and lung tissue components were performed. In vivo exposure of small animals to NO2 and cigarette smoke has been interpreted in terms of pollutant reaction with the heme moiety of hemoglobin. Results imply that the pollutants have migrated through the erythrocyte membrane. So as to understand the effects of these pollutants upon the membranes themselves, various model systems have been studied, particularly the interaction of nitrogen dioxide with unsaturated lipids.Three stable free radicals have been characterized as products of these reactions; and a short-lived initial free radical was observed, the structure of which provides evidence as to the initial reaction site and mechanism.Speci fi c physiological damage has been attributed to the oxidants present in the atmosphere-especially nitrogen oxides and ozone. Ari oka1 demonstrated that pulmonary dam¬ age was experimentally induced in rats by inhalation of nitrogen diox¬ ide. He successfully demonstrated a relationship between the mortality rate and the N02 concentration, and he also showed that the blood of the exposed rats contained an elevated concentration of both metmyoglobin (4% to 6%) and potassium ions. Sy-mon2 has reported that elevated lev¬ els of metmyoglobin (3% to 5%) have been observed in children living in an environment containing high con¬ centrations of oxides of nitrogen.Studies by Thomas et al3 concerned with the effects of NO, on young rats have demonstrated that the in¬ halation of 1 ppm for one hour or 0.5 ppm for four hours leads to sig¬ nificant morphological changes in their lung-mast cells. The morpho¬ logical changes are thought to occur both as a result of the chemical in¬ teraction of N02 with the cell mem¬ brane and as a result of the inter¬ action of N02 with certain specific but undefined cellular elements which lead to a loss in cell integrity. Thomas et al4 have reported ab¬ sorption spectroscopic evidence of lipid peroxidation from extracts of the lungs of rats which have been ex¬ posed to 1 ppm atmospheres of NO, for both single periods of four hours and repeated four-hour exposures over a period of six days. Their re¬ sults suggested that the extent of peroxidation was cumulative. These authors also report that structural changes are induced in the lung lipids upon exposure to N02.In vitro studies aimed at elucidat¬ ing products and mechanisms associ¬ ated with observed in vivo effects have included work by Feimeister et al5 on surface pressure measure¬ ments of films of both saturated and unsaturated phospholipids. They find that, whereas no observable inter¬ actions were observed in the case of the saturated phospholipids, films of egg lecithin, an unsaturated phos¬ pholipid, showed significant changes in the surface pressure-surface area curves in the presence of all atmo¬ spheres studied which contain N02. They attribute their observed effects to a chemical interaction of N02 with the double bonds of the lecithin.Our stud...

show abstract

Electron spin resonance and optical studies of the interaction between NO2 and unsaturated lipid components

Cited by 16 publications

References 10 publications

Tansley Review No. 24 Why are atmospheric oxides of nitrogen usually phytotoxic and not alternative fertilizers?

Tansley Review No. 24 Why are atmospheric oxides of nitrogen usually phytotoxic and not alternative fertilizers?

Adsorption of nitrogen oxides by the moisture-saturated zeolites in gas stream

Reaction of Nitrogen Dioxide With Blood and Lung Components

Contact Info

Product

Resources

About