Electron rich substituted β-carboline derivatives: Synthesis and photophysical properties

β-Carboline-based light and pH dual stimuli-responsive ion transporters induce cancer cell death

“…The protonation of the pyridyl ring of the b-carboline moiety of 4a could significantly affect the Cl À -transport properties in an acidic medium (pK a 5.78). 13 The potent compound would remain mostly in the protonated form at pH 5.5. The lucigenin-based Cl À -transport studies showed that 4a has a higher Cl À -transport propensity in an acidic medium (pH 5.5; EC 50 = 0.20 AE 0.03 mM) than under physiological conditions (pH 7.2; EC 50 = 1.44 AE 0.05 mM) (Fig.…”