At very high energies, pair production (γ → e + e − ) exhibits many interesting features. The momentum transfer from the target is very small, so the reaction probes the macroscopic properties of the target, rather than individual nuclei. Interference between interactions with different atoms reduces the pair production cross section considerably below the Bethe-Heitler values. At very high energies, photonuclear interactions may outnumber pair production.In contrast, in crystals, the interaction amplitudes may add coherently, greatly increasing the cross sections. Pair production in matter-free magnetic fields is also possible. The highest energy pair production occurs at high energy particle colliders. This article will compare pair production in these very different regimes.