Electron paramagnetic resonance of radicals induced in drugs and excipients by radiation or mechanical treatments

Abstract

Radiation as well as mechanical treatments induced in drugs and excipients radicals, which can be studied by electron paramagnetic resonance. A special attention is pointed about the use of electron paramagnetic resonance (EPR) to bring the proof whether or not a drug has been irradiated or not. We also discuss of other methods (thermoluminescence (TL), gas phase chromatography (GPC)) which can be used to bring the same proof in case of irradiated drugs, excipients and cosmetic products.

Detection of caraway and bay leaves irradiation based on their extracts’ antioxidant properties evaluation

“…by Yordanov and Georgieva (2004). The effect of mechanical treatment on radical production in lactose and carboxymethylcellulose was described by Raffi et al (2002). The presence of radicals originating from grinding process was noticed also in c-irradiated black pepper and clove samples Polovka et al, 2007;.…”

Electron paramagnetic resonance of rγ-irradiated glycyl-L-glutamine monohydrate, iminodiacetic acid and methyliminodiacetic acid

“…Ionizing radiation (gamma rays from 60 Co or 137 Cs sources, X-rays and electron beams) has been used for a long time in order to sterilize medical devices, to improve hygienic quality of food or for sterilization of drugs and cosmetics [1][2][3][4][5]. It is well known that free radicals can be produced by high-energy radiation and they can be studied by the electron paramagnetic resonance (EPR) technique.…”

The effect of gamma radiation of amino acid derivatives in the solid state: an EPR study

“…The main problem of damage of ionizing radiations on amino acids and drugs is the possibility of chemical and physical alterations, which can lead to loss of their biological activity. (5,6) It is known that electron paramagnetic resonance (EPR) spectroscopy is a very sensitive method for the detection of free radicals. It can be used for studying the radiolysis mechanism or for the detection of irradiated amino acids and drugs where unpaired electron is included.…”