Electron Paramagnetic Resonance Investigation of Radiation Effect on Certain Types of Drug Powders

Abstract

In this study, gamma rays were applied to the sulfadimethoxine, pyrazinamide, and chloramphenicol in the dose range of 1-15 kilogray, in order to detect radiosensitivity of paramagnetic species, which are formed after irradiation by electron paramagnetic resonance spectroscopy. Firstly, the intensities of electron paramagnetic resonance signals of the samples as a function of the microwave power were investigated at room temperature. While no signal was obtained from the unirradiated samples, the irradiated samples exhibited significant spectra. Additionally, the time dependency of the samples was analyzed to study the stability of the radicals.