1963
DOI: 10.1002/cne.901200107
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Electron microscopy of Wallerian degeneration

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Cited by 112 publications
(19 citation statements)
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“…Axotomy, perhaps the most severe axonal insult, results in catastrophic fragmentation of the portion of the axon distal to the injury site [48,49]. A similar morphological fragmentation has been observed in Parkinson’s disease, Huntington’s disease, and Multiple Sclerosis [50].…”
Section: Axon Degeneration After Injury: Wallerian Degenerationmentioning
confidence: 87%
“…Axotomy, perhaps the most severe axonal insult, results in catastrophic fragmentation of the portion of the axon distal to the injury site [48,49]. A similar morphological fragmentation has been observed in Parkinson’s disease, Huntington’s disease, and Multiple Sclerosis [50].…”
Section: Axon Degeneration After Injury: Wallerian Degenerationmentioning
confidence: 87%
“…The later shows a striking histological similarity with Wallerian Degeneration (WD). WD is a mode of degeneration that occurs after an axon is severed in the periphery or in the CNS; it begins with a latent phase and continues with the extensive fragmentation of the axon cytoskeleton and disintegration of internal organelles distal to the injury site, concluding with the complete breakdown of the axon distal to the injury site (Coleman & Freeman 2010, Lee 1963, Thomas 1964, Thomas & Sheldon 1964). WD was initially thought to be the passive degradation of the distal axon due to the lack of soma-derived trophic support.…”
Section: Pruning Versus Degenerationmentioning
confidence: 99%
“…Recent electron microscope findings (2)(3)(4)(5) suggested to us that the behavior of cell organelles might better be understood when the lysosomes in axoplasm and Schwann cells were investigated.…”
Section: Introductionmentioning
confidence: 99%