Electron microscopical study of rowson‐parr virus infection in balb/c mice

BALB/c mice infected with Rowson-Parr virus, a lymphatic leukemia virus isolated from the Friend complex, undergo a rapid depression of antibody response. Spleen cells from these mice in culture show a similar deficit in the response to stimulation with sheep red cells and inhibit the reactivity of normal splenocytes. In an attempt to reverse this immunosuppression, near normal responses were obtained in vitro from infected splenocytes by increasing antigen dose, by adding E. coli lipopolysaccharide, or, more effectively, by cocultivating with small numbers of unfractionated or T cell-depleted peritoneal exudate cells (PC), whereas other manipulations proved ineffective. PC did not prevent the inhibition of normal splenocytes by infected spleen cells, but exhibited substantial restorative activity in vivo. In similar experiments, the immunosuppression exerted by the entire Friend complex could be reversed by PC in vitro but not in vivo. These results indicate that a functional deficit of macrophages may be partially responsible for the immunological impairment induced by leukemia viruses and suggest rational approaches to evaluate the relevance of this impairment to oncogenesis.

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Immunodepression by Rowson-Parr virus in mice; lymphocyte markers and capping response of spleen and lymph node cells after infection

Bendinelli¹,

Friedman²

1976

Infect Immun

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Infection with Rowson-Parr virus (RPV) induced a rapid reduction in the number of immunoglobulin-positive and theta antigen-positive cells detectable by immunofluorescence in the spleens of susceptible BALB/c mice. The changes produced by RPV infection in the lymph nodes were different, since the number of immunoglobulin-positive cells was increased and the proportion of theta-positive cells remained unchanged. However, the ability of immunoglobulin-bearing cells to redistribute their receptors into caps was reduced in both types of lymphoid tissue. A similar pattern of changes was produced by infection with Friend leukemia complex, from which RPV was originally obtained. These effects of RPV and Friend leukemia complex may contribute to the immunodepressed state of infected mice.

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Electron microscopical study of rowson‐parr virus infection in balb/c mice

Abstract: The significant electron microscopic changes in the course of Rowion-Parr virus infection in

Cited by 4 publications

References 11 publications

Glomerular Immune Complex Disease in Rowson-Parr Virus Infection of BALB/c Mice

Glomerular Immune Complex Disease in Rowson-Parr Virus Infection of BALB/c Mice

Reversal of Immunosuppression Induced by Murine Leukemia Viruses*

Immunodepression by Rowson-Parr virus in mice; lymphocyte markers and capping response of spleen and lymph node cells after infection

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