“…With regard to actin, other investigators have suggested that this cytoskeletal protein may not be required for any specific function in the compacted nuclear fiber cells . Although an accelerated loss of vimentin has been reported to occur in the nucleus of human nuclear cataracts (Ozaki, Jap and Bloemendal, 1985), a finding similar to the results of this study with HBO, vimentin-knockout mice, surprisingly, have been found to possess a normal lens cortex and nucleus (Colucci-Guyon et al, 1994). Regarding lens cortical changes, HBO-treatment produced no increased scatter or loss of cytoskeletal proteins in that region.…”