Electron Microscopic Analysis of the Secretion Mechanism

An Electron Microscopic Study of the Olfactory Mucosa in the Bat and Rabbit

“…On the other hand, however, it can be presumed that they may possibly indicate the discharge of some unknown substance into the mucous film by a mechanism like the microapocrine process proposed by KUROSUMI (1961), because bubble-like processes are supposed to be liberated by pinching off at the constricted basal portion into the mucous film. (FRISCH, 1967;GRAZIADEI, 1972 etc.…”

“…Among several mechanisms of discharge of secretory granules into extracellular space (KUROSUMI, 1961), the so-called emiocytotic or reverse-pmocytotic process has been most widely confirmed both in exocrine and endocrine glands. In both bat and rabbit olfactory glands, secretory granules elaborated in the Golgi area show a tendency to migrate toward the luminal area of the secretory cells to be found immediately beneath the plasma membrane lining the luminal surface, but actual cytological signs indicating their emiocytotic discharge into the glandular lumen have not been verified in the present study, although it has been revealed by some authors in mucous cells, for example in goblet cells (ITO and ISHII, 1970).…”

The Correlative Light and Electron Microscopy of the Islets of Langerhans in Some Lower Vertebrates

“…Concerning A-cells, it seems safe to conclude that the granules are released mainly by the eruptocrine or Type IV extrusion mechanism (KUROSUMI, 1961) as reported by many investigators (MACHINO, 1966;MACHINO, ONOE and SAKUMA, 1966;PRZYBYLSKI, 1967;GOMEZ-ACEBO, PARRILLA and R-CANDELA, 1968). The eruptocrine mechanism is sometimes called emiocytosis which was named by LACY (1962).…”

“…The eruptocrine mechanism is sometimes called emiocytosis which was named by LACY (1962). As for the B-cells a majority of investigators (KOHAMA, 1968) have proposed diacrine or Type V extrusion mechanism (KUROSUMI, 1961), although some investigators suggested Type IV extrusion (LACY, 1962;WILLIAMS and ENSINCK, 1966 …”

“…However, still some problems have remained such as the extrusion mode of the islet cell granules especially of B-cells, which was postulated by some investigators to be diacrine (FUJITA and MATSUNO, 1967;KOHAMA, 1968) or KUROSUMI'S (1961) Type V, whereas by others it is thought to be eruptocrine (LACY, 1962;BJORKMAN et al, 1963;WILLIAMS and ENSINCK, 1966) or a Type IV mechanism (KUROSUMI, 1961).…”