Electron microscope studies on the subcommissural organ of the guinea pig

The Fine Structure of the Subcommissural Organ of the Human Fetus

“…Similar structure has been also reported in the cells of this organ of some vertebrates, and it has been postulated that this structural configuration is closely associated with protein synthesis, hence with production of secretion (frog: MURAKAMI and TANIZAKI 1963;calf: ISOMAKI et al, 1965;guinea pig: VIGH et al, 1967;PAPACHARALAMPOUS et al, 1968). It may be then suggested that this structure has merely a phylogenetic significance in man.…”

“…The apical cell surface is sometimes followed into the ventricle by pseudopod-like projections of various shapes and sizes which are smoothly outlined and are free from such cellular organelles Upon the surface of the subcommissural cells facing the third ventricle, a laree number of microvilli, some cytoplasmic protrusions of the subcommissural as mitochondria and the granular endoplasmic reticulum except for a cluster of glycogen granules in some instances. Such cytoplasmic protrosions have been reported in the subcommissural cells of some species and interpreted as suggesting microapocrine secretion (in lamprey by STERBA et al, 1967; in bony fish by STANKA, 1967; in calf by ISOMAKI et al; in guinea pig by VIGH et al, 1967 andPAPACHARALAMPOUS et al, 1968;in mouse by IMAIZUMI, 1968). In spite of these many reports, the possibility that they may be an artifact produced during the process of fixation cannot be absolutely discarded.…”

The subcommissural organ

“…presented ultrastructural evidence suggesting that secretory vesicles derived from the RER would bypass the Golgi apparatus and release its secretory content into the ventricle; this mechanism would coexist with the classical secretory pathway including the Golgi channels (Chen et al, 1973;Murakami and Tanizaki, 1963;Oksche, 1969;Papacharalampous et al, 1968;Rodríguez, 1970a;Stanka et al, 1964). Recent ultrastructural immunocytochemistry and lectin histochemistry have not clarified this aspect.…”

Electron Microscopic Observation of the Subcommissural Organ in the Soft-shelled Turtle, <i>Amyda japonica</i>

“…1). MURAKAMI andTANIZAKI, 1963, fishes: STERBA et al, 1967;STANKA, 1967, guinea pigs: VIGH et al, 1967PAPACHARALAMPOUS et al, 1968 (Fig. 1).…”

“…The ultrastructure of secretory ependymal cells constituting the subcommissural organ (SCO) which is situated on the roof of the third cerebral ventricle below the posterior commissure has recently been studied in fishes (AFZELIUS and OLSSON, 1957;MURAKAMI and TANIZAKI, 1966;STERBA, MULLER and NAUMANN, 1967;STANKA, 1967;ALTNER, 1968), amphibians (MURAKAMI and TANIZAKI, 1963;ALTNER, 1968), reptiles (MURAKAMI, 1959;MURAKAMI, KUSABA and YAMAKAWA, 1962) and mammals (ANDERSON, 1961;LIN and DUNCAN, 1961;WETZSTEIN, SCHWINK and STANKA, 1963;NAUMANN and VOLFE, 1963;LAATSCH, 1964;STANKA, WETZSTEIN and SCHWINK, 1964;ISOMAKI, KIVALO and TALANTI, 1965;HERRINGER, SCHWINK and WETZSTEIN, 1967;VIGH et al, 1967;BARLOW, AGOSTINO and CANCILLA, 1967;PAPACHARALAMPOUS, SCHWINK and WETZSTEIN, 1968;IMAIZUMI, 1968).…”