Electron microscope observations on Langerhans cells in the cervix

CD1a-positive infiltrating-dendritic cell density and 5-year survival from human breast cancer

“…S-100 is a small acidic regulatory protein involved in a wide range of cellular processes and exhibits relative tissue specificity for DCs and cells of neural origin, including melanoma cells (Heizmann et al, 2002). The density of DCs, using either CD1a or S-100 as markers for DC, has been reported for a variety of human cancers including cervix (Younes et al, 1968;Bethwaite et al, 1996), ovary (Eisenthal et al, 2001), lung (Bassett et al, 1974;Fox et al, 1989;Zeid and Muller, 1993), larynx (Schenk, 1980), salivary glands (David and Buchner, 1980), skin (Gatter et al, 1980), breast (Hillenbrand et al, 1999;Coventry et al, 2002), thymus (Hammar et al, 1986), oesophagus (Matsuda et al, 1990), stomach (Tsujitani et al, 1987), pancreas (Dallal et al, 2002), thyroid (Schroder et al, 1988;Willgeroth et al, 1992), colon (Ambe et al, 1989), nasopharynx (Nomori et al, 1986;Gallo et al, 1991a;laryngeal (Gallo et al, 1991b)), oral (Kikuchi et al, 2002), prostate, bladder and kidney (Bigotti et al, 1991;Inoue et al, 1993;Troy et al, 1998aTroy et al, , b, 1999. Furthermore, DC numbers, as measured using either CD1a or S-100 antibodies, have been positively associated with improved outcome (increased survival) for many of these cancers, although the mechanism remains unclear.…”

Antigen Recognition in the Female Reproductive Tract. II. Endocytosis of Horseradish Peroxidase by Langerhans Cells in Murine Vaginal Epithelium1

“…cells (LCs) are present in the stratified epithelium of the vagina and cervix, but little is known about their function at these sites [1][2][3][4][5][6][7][8][9]. LCs …”

Epithelial Kinetics Affect Langerhans’ Cells of Mouse Vaginal Epithelium

“…Wolff (1972) has pointed out that Langerhans cells are found in stratified squamous epithelia, other than skin epithelia, that have the capacity to keratinize. They have been demonstrated in gingival epithelium (Waterhouse and Squire, 1967); vaginal epithelium (Younes et al. 1968);tonsil (Mâusle et al, 1971); sheep rumen (Gemmell, 1973), and oesophagus (Al Yassin and Toner, 1976).…”