Electron-Capture GLC Determination of Pseudoephedrine in Serum

Sun, Sy-Rong; Leveque, Mary Jo

doi:10.1002/jps.2600681232

Cited by 5 publications

(1 citation statement)

References 5 publications

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“…The developed method was used for the determination of PSH in pharmaceutical formulations and serum samples. During the 24h interval following oral ingestion of 180 mg of PSH, serum concentrations ranging from~0.1 to 0.8 µ g mL −1 are expected [18].…”

Section: Introductionmentioning

confidence: 99%

A Novel Fluorimetric Method for Determination of Pseudoephedrine Hydrochloride in Pharmaceutical Formulations and Blood Serum

Farajzadeh

Nader

2020

Turk J Chem

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An inexpensive, simple, highly sensitive, and rapid fluorimetric method was developed for the analysis of pseudoephedrine hydrochloride at trace levels. The method is based on the recovery of fluorescence of Rh6G dye due to the interaction of pseudoephedrine hydrochloride with Rh6G-Au NPs complex, which results in the release of Rh6G from the complex and halting fluorescence resonance energy transfer between Rh6G and Au NPs. The intensity of fluorescence was directly proportional to the concentration of the analyte, which was used for its determination. Experimental factors were optimized by response-surface methodology. Under optimum conditions, the calibration curve was linear over the range of 15-150 ng mL −1 and the limit of detection (LOD) was 10 ng mL −1 . Percent relative standard deviation (n = 5) for determination of 50 ng mL −1 pseudoephedrine hydrochloride was 3.74%. The method was successfully used for determining the analyte in human blood serum and in pharmaceutical formulations. The possible mechanistic description of the analytical reaction was proposed on the basis of TEM, FT-IR, and fluorescence spectra analysis.

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Section: Introductionmentioning

confidence: 99%

A Novel Fluorimetric Method for Determination of Pseudoephedrine Hydrochloride in Pharmaceutical Formulations and Blood Serum

Farajzadeh

Nader

2020

Turk J Chem

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Simultaneous quantification of ephedrines in urine by high-performance liquid chromatography

Merwe

Brown

Hendrikz

1994

Journal of Chromatography B: Biomedical Sciences and Applicatio

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Derivatization reactions in the gas—liquid chromatographic analysis of drugs in biological fluids

Hulshoff¹,

Lingeman²

1984

Journal of Pharmaceutical and Biomedical Analysis

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Alkylation, acylation, silylation and other derivatization reactions applied to the gas chromatographic analysis of drugs in biological matrices are reviewed. Reaction conditions are discussed in relation to reaction mechanisms. Detector-oriented labelling of drugs, and derivatization with chiral reagents for the separation of enantiomers are surveyed. Data on the sample clean-up, derivatization and GLC analysis of more than 300 drugs and related compounds are listed.

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Electron-Capture GLC Determination of Pseudoephedrine in Serum

Cited by 5 publications

References 5 publications

A Novel Fluorimetric Method for Determination of Pseudoephedrine Hydrochloride in Pharmaceutical Formulations and Blood Serum

A Novel Fluorimetric Method for Determination of Pseudoephedrine Hydrochloride in Pharmaceutical Formulations and Blood Serum

Simultaneous quantification of ephedrines in urine by high-performance liquid chromatography

Derivatization reactions in the gas—liquid chromatographic analysis of drugs in biological fluids

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