Electron beam tomography comparison of culprit and non-culprit coronary arteries in patients with acute myocardial infarction

Mascola, Anthony; Ko, John Y.; Bakhsheshi, Hamid; Budoff, Matthew J.

doi:10.1016/s0002-9149(00)00768-2

Cited by 14 publications

(2 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most patients presenting with an acute ischemic event have detectable CAC [26,27]. In some of these studies, IVUS has demonstrated frequent calcification of the culprit lesion [28][29][30]. The calcifications noted, tend to be small and often show a spotty pattern [30,31].…”

Section: Detectionmentioning

confidence: 99%

Calcium Scoring and Contrast-Enhanced CT Angiography

Sanz¹,

Dellegrottaglie²,

Fuster³

et al. 2006

CMM

View full text Add to dashboard Cite

Computed tomography (CT) technology has emerged as the most promising imaging modality for the noninvasive evaluation of the coronary circulation. Of the CT-based approaches, multidetector-row computed tomography (MDCT) and to a lesser extent electron beam computed tomography offer the potential of providing not only data on the spatial extent and burden of coronary calcium content, but also angiographic data, and plaque composition characteristics with the potential for prediction of susceptibility to future cardiovascular events. A number of studies have now confirmed that CT-based assessment of the presence and amount of coronary artery calcium provides incremental prognostic information over traditional risk factors in patients with coronary artery disease and can be employed to refine risk stratification in both asymptomatic and symptomatic subjects. With the advent of several recent advances in CT imaging, it is now possible to provide high resolution (sub-millimeter, isotropic voxels) images of the coronary arteries obtained rapidly with iodinated contrast injected peripherally. MDCT is currently the preferred modality for noninvasive contrast angiography of the coronary arteries by most groups, with a new generation of 64-slice scanners promising to further improve the results of this technique. MDCT-derived angiographic information in conjunction with coronary calcium scoring and plaque characterization has the potential of replacing invasive angiography, as it potentially could provide better global assessment of risk.

show abstract

Section: Detectionmentioning

confidence: 99%

Calcium Scoring and Contrast-Enhanced CT Angiography

Sanz¹,

Dellegrottaglie²,

Fuster³

et al. 2006

CMM

View full text Add to dashboard Cite

show abstract

“…13 Recent studies have shown detectable coronary calcifications in 95% of patients with acute coronary syndromes. 14 15 However, in younger individuals, coronary events often occur in the presence of early stages of coronary artery disease, presumably caused by the rupture of lipid-rich coronary plaques, [16][17][18] and coronary calcification may be less prevalent than in older patients with acute myocardial infarction. 19 The value of electron beam tomography in detecting relatively young patients at risk of acute myocardial infarction is therefore less clear and has so far not been investigated.…”

mentioning

confidence: 99%

Coronary calcifications in young patients with first, unheralded myocardial infarction: a risk factor matched analysis by electron beam tomography

Pohle

Ropers

Mäffert

et al. 2003

Heart

View full text Add to dashboard Cite

Objective: To compare the presence and extent of coronary calcifications in young patients with first, unheralded acute myocardial infarction with matched controls without a history of coronary artery disease. Methods: In 102 patients under 60 years of age (19-59 years, mean 41 years; 88% male), electron beam tomography was done 1-14 days after acute myocardial infarction, before any coronary intervention. Coronary calcifications were quantified using the Agatston score. Age related calcium centiles were determined based on the Mayo Clinic "epidemiology of coronary calcification" study, and results were compared with a group of 102 controls without coronary artery disease, matched for sex, age, and risk factors. Results: Calcifications were present in 95.1% of patients with acute myocardial infarction and in 59.1% of controls (p = 0.008). The mean (SD) Agatston score was 529 (901) in the infarct patients versus 119 (213) in the controls (p < 0.001). An Agatston score above the 50th centile was present in 87.2% of infarct patients and 47.0% of controls (p = 0.006), and above the 90th centile in 60.7% of infarct patients and only 5.8% of controls (p = 0.001). Conclusions: In young patients with their first, unheralded acute myocardial infarction, the presence and extent of coronary calcium are significantly greater than in matched controls. E lectron beam tomography is a sensitive tool for detecting and quantifying coronary calcifications.1 The amount of coronary calcium correlates with the amount of coronary atherosclerotic plaque.2-5 Thus the presence and extent of coronary artery calcification has been shown to be associated with an individual's risk for cardiovascular events. [6][7][8][9][10][11][12] In up to 50% of patients who suffer an acute myocardial infarct, this event is the first clinical manifestation of coronary artery disease. 13 Recent studies have shown detectable coronary calcifications in 95% of patients with acute coronary syndromes.14 15 However, in younger individuals, coronary events often occur in the presence of early stages of coronary artery disease, presumably caused by the rupture of lipid-rich coronary plaques, [16][17][18] and coronary calcification may be less prevalent than in older patients with acute myocardial infarction. 19 The value of electron beam tomography in detecting relatively young patients at risk of acute myocardial infarction is therefore less clear and has so far not been investigated.Our aim in this study was to assess the prevalence and the extent of coronary calcification in younger patients with a first, unheralded acute myocardial infarct in comparison with matched controls without a history of coronary artery disease. METHODS Patients and controlsWe recruited 102 patients under 60 years of age with an unheralded, first transmural myocardial infarct established by ST elevation on the ECG and increased serum markers of myocardial damage (creatine kinase, creatine kinase MB isoenzyme, and troponin C). Patients with a previously established diagnosis of coronary ...

show abstract

Assessment of Cardiovascular Calcium: Interpretation and Relevance of Calcium Scoring Relationship to Lipids and Other Cardiovascular Risk Factors

Hecht

Cardiac CT Imaging

View full text Add to dashboard Cite

Electron beam tomography comparison of culprit and non-culprit coronary arteries in patients with acute myocardial infarction

Cited by 14 publications

References 19 publications

Calcium Scoring and Contrast-Enhanced CT Angiography

Calcium Scoring and Contrast-Enhanced CT Angiography

Coronary calcifications in young patients with first, unheralded myocardial infarction: a risk factor matched analysis by electron beam tomography

Assessment of Cardiovascular Calcium: Interpretation and Relevance of Calcium Scoring Relationship to Lipids and Other Cardiovascular Risk Factors

Contact Info

Product

Resources

About