Electron Beam Computed Tomographic Coronary Calcium as a Predictor of Coronary Events

Secci, Angelo; Wong, Nathan D.; Tang, Weiyi; Wang, Shaojun; Doherty, Terence M.; Detrano, Robert

doi:10.1161/01.cir.96.4.1122

Cited by 168 publications

(82 citation statements)

References 35 publications

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“…The predictive value of the overall calcium score for future coronary events is well established and an incremental value of calcium scores over clinical risk-assessment in selected patient groups with intermediate risk has been shown [30][31][32][33] . In one study, 10,377 asymptomatic individuals were followed with the objective of developing risk-adjusted multivariable models that included risk factors and coronary calcium scores for the prediction of all-cause mortality 32 .…”

Section: Ct Calcium Scoringmentioning

confidence: 99%

Métodos por imagem da aterosclerose em estudos de progressão/regressão: marcador substituto ou janela direta para o processo patológico da aterosclerose?

Schoenhagen¹,

Tuzcu²

2008

Arq. Bras. Cardiol.

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SummaryCAD remains a major global cause of morbidity and mortality. Comprehensive drug development programs of novel pharmacological treatment strategies frequently utilize traditional mortality/morbidity endpoints studies and additional surrogate endpoints trials. This parallel approach allows an assessment of efficacy several years in advance of the availability of data from clinical endpoint trials. Several atherosclerosis imaging markers have been introduced into these drug-development strategies, including angiography, carotid ultrasound, IVUS, MRI, and CT. This review will discuss the current status of atherosclerosis imaging as an endpoint in progression/regression trials, with an emphasis on evidence-based data. In addition to a discussion of the results of individual imaging modalities, the emerging data comparing different modalities and approaches are presented.

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Section: Ct Calcium Scoringmentioning

confidence: 99%

Métodos por imagem da aterosclerose em estudos de progressão/regressão: marcador substituto ou janela direta para o processo patológico da aterosclerose?

Schoenhagen¹,

Tuzcu²

2008

Arq. Bras. Cardiol.

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“…[15][16][17][18] The National Heart, Lung, and Blood Institute (NHLBI) recently put forward an RFP (request for proposals) using EBCT, among other noninvasive methods, to study subclinical cardiovascular disease (RFP-…”

mentioning

confidence: 99%

Electron Beam Computed Tomographic Coronary Calcium Scanning: A Review and Guidelines for Use in Asymptomatic Persons

Rumberger

Brundage²,

Rader

et al. 1999

Mayo Clinic Proceedings

739

442

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“…1,2 Previous studies have shown the close relationships between arterial wall calcification and abnormal serum lipid levels. Arterial wall calcification is common in patients with familial hypercholesterolemia, a genetic disorder of cholesterol metabolism.…”

mentioning

confidence: 99%

Pulse Pressure Is an Independent Predictor for the Progression of Aortic Wall Calcification in Patients With Controlled Hyperlipidemia

et al. 2004

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Abstract-Recent epidemiological studies suggested that calcifications of the aorta and the coronary arteries are important predictors for cardiovascular morbidity and mortality. However, the relation between blood pressure components and the progression of vascular wall calcification has remained unclear. We quantified calcium deposits in the abdominal aorta as the percentage of aortic calcification volume (%ACV) using computed tomography in patients with hyperlipidemia. Those who had aortic calcification were treated with lipid-lowering agents and followed-up for Ͼ2 years (6.3Ϯ3.2 years). The relationship between the components of blood pressure and the increase in %ACV per year (⌬%ACV/year) was assessed in subjects in whom serum lipid levels were well controlled during the follow-up periods. An age-and sex-adjusted correlation analysis showed that ⌬%ACV/year was significantly correlated to body mass index (rϭ0. Key Words: hypertension Ⅲ calcium Ⅲ aorta Ⅲ pulse Ⅲ imaging Ⅲ risk factors C alcification in the aorta and coronary arteries is a strong predictor for cardiovascular morbidity and mortality. 1,2 Previous studies have shown the close relationships between arterial wall calcification and abnormal serum lipid levels. Arterial wall calcification is common in patients with familial hypercholesterolemia, a genetic disorder of cholesterol metabolism. [3][4][5] Several studies have identified the relationship between the serum level of low-density lipoprotein cholesterol (LDL-C) and arterial wall calcification; moreover, lipid-lowering therapy using 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors has been reported to inhibit the progression of arterial wall calcification. 6,7 In patients receiving long-term hemodialysis, elevated serum triglyceride (TG) levels and reduced high-density lipoprotein cholesterol (HDL-C) levels are risk factors for coronary artery calcification. 8 These studies suggested that abnormal serum lipid levels promote calcium deposition in the arterial wall.Several studies have examined the influence of hypertension on the progression of arterial wall calcification. In these studies, antihypertensive therapy has been shown to inhibit the formation of calcified lesions, suggesting that hypertension promotes calcium deposition in the arterial wall. 9 -11 However, it remains undetermined which blood pressure (BP) component, ie, systolic BP (SBP), diastolic BP (DBP), mean BP (MBP), or pulse pressure (PP) is responsible for the accelerated formation of calcification, probably because the abnormal serum lipid levels may have made it difficult to assess the effect of BP alone on the formation of calcified lesions.Computed tomography (CT) is a useful tool to evaluate the level of arterial wall calcification. Most of the previous studies used the "calcium score" determined by CT as a semiquantitative index of calcification of the aorta or coronary arteries. [3][4][5][6][7] However, the calcium score may not accurately reflect subtle changes in calcium deposit levels. To accurat...

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Electron Beam Computed Tomographic Coronary Calcium as a Predictor of Coronary Events

Abstract: Calcium quantities from the 3-mm and the more reproducible 6-mm scanning are equally accurate for predicting events. Coronary calcium amount appears to be a weak predictor of coronary death and infarction. Its predictive accuracy is superior for predicting revascularization.

Cited by 168 publications

References 35 publications

Métodos por imagem da aterosclerose em estudos de progressão/regressão: marcador substituto ou janela direta para o processo patológico da aterosclerose?

Métodos por imagem da aterosclerose em estudos de progressão/regressão: marcador substituto ou janela direta para o processo patológico da aterosclerose?

Electron Beam Computed Tomographic Coronary Calcium Scanning: A Review and Guidelines for Use in Asymptomatic Persons

Pulse Pressure Is an Independent Predictor for the Progression of Aortic Wall Calcification in Patients With Controlled Hyperlipidemia

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