1977
DOI: 10.1097/00006534-197707000-00007
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Electron and Light Microscopy Examination of Capsules Around Breast Implants

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Cited by 48 publications
(10 citation statements)
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“…In this day 28 group, an increase in serum IL-6 suggested the presence of a subclinical systemic inflammatory response although there were no obvious signs of infection or surgical complications. These data highlight the complexity of capsule formation and fibrosis 715 and suggest that other factors such as subclinical infection that were not assessed in our study may be involved in the process. 32–34 …”
Section: Discussionmentioning
confidence: 70%
“…In this day 28 group, an increase in serum IL-6 suggested the presence of a subclinical systemic inflammatory response although there were no obvious signs of infection or surgical complications. These data highlight the complexity of capsule formation and fibrosis 715 and suggest that other factors such as subclinical infection that were not assessed in our study may be involved in the process. 32–34 …”
Section: Discussionmentioning
confidence: 70%
“…With in vivo silicone implantation, postoperative formation of a fibrous connective tissue capsule around the silicone implant is inevitable [3,13,30,32]. Essentially, the formation of this capsule is one of the body's defense mechanisms to completely isolate foreign bodies [7,9,[30][31][32]. Vistnes et al [30] reported that in the acute stage of the initial inflammatory response, if phagocytes failed to remove large implants as a silicone sheet, collagenous fibers would infiltrate and be arranged directly around the implant to form a fibrous tissue capsule isolating the foreign body.…”
Section: Discussionmentioning
confidence: 99%
“…During the entire chronic stage, acid mucopolysaccharides were associated predominantly with the collagenous fibers. The foreign body reaction process that produces the fibrous capsule continues as long as the implant is present but disappears when the silicone sheet is completely removed [30][31][32]. Formation and development of this fibrous capsule are influenced by several factors such as properties of the silicone implant [7,30], local surgical trauma [9,14,30], postoperative formation of seroma or hematoma [30], and bleeding from local small vessels [29][30][31].…”
Section: Discussionmentioning
confidence: 99%
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“…9 Nevertheless, polyurethane implants have not gained much popularity because of the carcinogenic risks of toluene diamine, a degenerative byproduct of polyurethane 10 ; the difficulty associated in removing textured prostheses 11 ; and significant foreign body reaction. 12 All this has caused some degree of confusion, with different implants being used in different parts of the world. 13 Although it is true that silicone is relatively inert, its tendency to fragment into miniscule particles 14 limits its interfacial biocompatibility, and this holds true for polyurethanes as well.…”
mentioning
confidence: 99%