Electromyographical Observations in Congenital Myotonia

Buchthal, Fritz; Clemmesen, Svend

doi:10.1111/j.1600-0447.1941.tb07412.x

Cited by 36 publications

(5 citation statements)

References 7 publications

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“…Physiology Department, University of Birmingham ATP has no direct ability to contract striated frog muscle (rectus abdominis in Ringer). When following the addition of ATP a contraction develops (Buchthal & Folkow, 1944;Buchthal, Deutsch & Knappeis, 1944) it is due according to our experiments to ACh (or a like substance) appearing in the bath. Many muscles are ATP refractive (Abdon, 1942).…”

Section: Psupporting

confidence: 57%

Proceedings of the Physiological Society

1951

The Journal of Physiology

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Section: Psupporting

confidence: 57%

Proceedings of the Physiological Society

1951

The Journal of Physiology

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“…The anomaly thus résides in an abnormal behavior of the muscle membrane whose action potential apparently triggers an autorhythmic process, as occurs normally in other excitable cells (see e.g., 98). In fact infiltration of the myotonic muscle with a local anesthetic can block the afterspasm selectively and so permit normal relaxation (9,42).…”

Section: Muscle Spike and Contractionmentioning

confidence: 99%

The Physio-Pathology of Neuromuscular Transmission and the Trophic Influence of Motor Innervation

Desmedt¹

1959

American Journal of Physical Medicine & Rehabilitation

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The long-neglected field of neurological diseases affecting the peripheral motor sj'stem is now being investigated with growing interest. Improved methods (19) have increased substantially the amount of information that can be extracted from biopsies of the neuromuscular junction in patients. On the otlier hand, biophysical research on vertebrates has recently harvested quite significant results about the elementary processes of nerve conduction (53), of neuromuscular transmission (16) and of muscular contraction (55). AU thèse and other advances undoubtedly call for more critical analyses of disturbed mechanisms in patients with motor impairment. It can be surmised that doser investigations are going to lead to a reconsideration of current neurological entities and to the isolation of new neuromuscular syndromes (e.g., 66). Significant progress along thèse lines will be promoted if the physiopathological and histopathological approaches are intimateh' correlated and if the functional significance of structural anomalies can be established. Indeed it is only by confronting observations coUected by either method on the same material that some of the pending problems can eventually be solved. PHYSI0-P.4TH0L0GY OF MOTOR INNERVATION Mere eommon sensé indicates that interruption of motor nerve fibers at any level will make the attached muscle fibers useless. More interesting for the purpose of the présent discussion arc those clinieal cases in which the anatomical continuity of the lower motor neuron is preserved. Such cases raise the problem of localizing the defective link in the chain of excitatory processes which enable the nerve impulse to elicit the contractile response.

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“…These potentials do not depend on motor neurone activity since they occur independently of willed movement and persist after impulse conduction in motor axons has been blocked (Buchthal and Clemmesen, 1941). The fact that d-tubocurarine is also ineffective in abolishing the action potentials (Floyd, Kent, and Page, 1955) indicates that they are not caused by acetylcholine acting at the end-plate or elsewhere along the fibre surface but must result from some intrinsic abnormality of the muscle fibre membrane.…”

mentioning

confidence: 99%