Electromembrane extraction (EME) and HPLC determination of non-steroidal anti-inflammatory drugs (NSAIDs) in wastewater samples

Ramos‐Payán, María; Bello‐López, Miguel Ángel; Torres, Rut Fernández; Villar-Navarro, Mercedes; Mochón, M. Callejón

doi:10.1016/j.talanta.2011.03.076

Cited by 120 publications

(44 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…High values of inter-electrode distance lead to decreased electrical field and extraction efficiency. On the other hand, very low inter-electrode distance lead to a general decrease in extraction efficiency [39]. Also, it is essential to control this parameter to obtain a reproducible extraction.…”

mentioning

confidence: 99%

Electromembrane extraction combined with cyclodextrin‐modified capillary electrophoresis for the quantification of trimipramine enantiomers

et al. 2012

View full text Add to dashboard Cite

A sensitive, simple and reproducible method was developed for preconcentration and determination of trimipramine (TPM) enantiomers in biological samples using electromembrane extraction combined with cyclodextrin-modified capillary electrophoresis (CE). During the extraction, TPM enantiomers migrated from a 5 mL sample solution through a thin layer of 2-nitrophenyl octyl ether NPOE immobilized in the pores of a hollow fiber, and into a 20 μL acidic aqueous acceptor phase presented inside the lumen of the fiber. A Box-Behnken design and the response surface methodology (RSM) were used for the optimization of different variables on extraction efficiency. Optimized extraction conditions were: NPOE as supported liquid membrane, inter-electrode distance of 5 mm, stirring rate of 1000 rpm, 51 V potential difference, 34 min as the extraction time, acceptor phase pH 1.0 and donor phase pH 4.5. Then, the extract was analyzed using optimized cyclodextrin (CD)-modified CE method for the separation of TPM enantiomers. Best results were achieved using 100 mM phosphate running buffer (pH 2.0) containing 10 mM α-CD as the chiral selector, applied voltage of 18 kV and 20°C. The range of quantitation for both enantiomers was 20-500 ng/mL. The method was very reproducible so that intra- and interday RSDs (n=6) were <6%. The limits of quantitation and detection for both enantiomers were 20 and 7 ng/mL, respectively. Finally, this method was successfully applied to determine the concentration of TPM enantiomers in plasma and urine samples without any pre-treatment.

show abstract

mentioning

confidence: 99%

Electromembrane extraction combined with cyclodextrin‐modified capillary electrophoresis for the quantification of trimipramine enantiomers

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Function generator 1 makes 6-s interrupts in every minute of the extraction and function generator 2 provides short potential pulses during the 6-s interrupts to obtain current time dependence. The sample compartment and the classical two-electrode assembly and the SLM composition were similar to previous works on the EME of SDF [13,31] but the extraction was carried out using the potential function generated by the above described circuitry. The pH of acceptor/donor solutions were adjusted by adding NaOH and or HCl.…”

Section: Chemicals and Reagentsmentioning

confidence: 99%

Impedometric monitoring of the behavior of the supported liquid membrane in electromembrane extraction systems: An insight into the origin of optimized experimental parameters

Mohammadi

Davarani

Moazami

2016

Analytica Chimica Acta

View full text Add to dashboard Cite

“…It has been demonstrated that EME method provides very efficient sample cleanup because of the hydrophobic organic membrane and small pore size of polypropylene membrane . This technique has been applied for acidic drugs , basic drugs , organic pollutants , metal ions , amino acids and herbicides . In recent years, a growing interest has been focused on developing efficient EME technique for the determination of peptides in biological matrices and is still in its infancy.…”

Section: Introductionmentioning

confidence: 99%

Quantification of controlled release leuprolide and triptorelin in rabbit plasma using electromembrane extraction coupled with HPLC–UV

2019

View full text Add to dashboard Cite

An electromembrane extraction followed by HPLC-UV technique was developed and validated for quantification of leuprolide and triptorelin in rabbit plasma. The influencing parameters on the extraction efficiency were optimized using experimental design methodology. The optimized conditions were found to be; supported liquid membrane: a mixture of 1-octanol and 2-ethyl hexanol (1:1) containing 10% v/v di(2-ethylhexyl) phosphate, applied voltage: 5 V, extraction time: 5 min, pH of the donor phase: 4.5 and pH of the acceptor phase: 1.0. The optimized method was validated for linearity, intraday and interday precision, and accuracy in rabbit plasma. The range of quantification for both peptides was 0.5-1000 ng/mL with regression coefficients higher than 0.994. Relative recoveries of leuprolide and triptorelin were found to be 80.3 and 75.5%, respectively. Limits of quantification and detection for both peptides were found to be 0.5 and 0.15 ng/mL, respectively. The validated method was successfully applied to pharmacokinetic study of the 1-month depot formulations of each peptide after subcutaneous administration to rabbits.

show abstract

Electromembrane extraction (EME) and HPLC determination of non-steroidal anti-inflammatory drugs (NSAIDs) in wastewater samples

Cited by 120 publications

References 32 publications

Electromembrane extraction combined with cyclodextrin‐modified capillary electrophoresis for the quantification of trimipramine enantiomers

Electromembrane extraction combined with cyclodextrin‐modified capillary electrophoresis for the quantification of trimipramine enantiomers

Impedometric monitoring of the behavior of the supported liquid membrane in electromembrane extraction systems: An insight into the origin of optimized experimental parameters

Quantification of controlled release leuprolide and triptorelin in rabbit plasma using electromembrane extraction coupled with HPLC–UV

Contact Info

Product

Resources

About