Electromechanical and biological evaluations of 0.94Bi0.5Na0.5TiO3–0.06BaTiO3 as a lead-free piezoceramic for implantable bioelectronics

Hall, Thomas A.G.; Theodoridis, Konstantinos; Kechagias, Stylianos; Kohli, Nupur; Denonville, Christelle; Rørvik, Per Martin; Cegla, Frederic; Arkel, Richard J. van

doi:10.1016/j.bioadv.2023.213590

Cited by 4 publications

(4 citation statements)

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“…The increased electroactivity may have adverse effects in periprosthetic bone if pH levels are not regulated in vivo, but direct current electrical stimulation systems, which induce microenvironmental changes in pH with currents below 60 μA, have been deemed safe for clinical use (Nicksic et al, 2022). In a clinical embodiment, the requisite signals for the active osseointegrative implant can also be generated using leadfree transducers (Hall et al, 2023), with components otherwise hermetically sealed. The effects of treatment amidst clot formation (haemostasis) (Shiu et al, 2014) and the restoration of blood supply (angiogenesis) (Grosso et al, 2017), which are both orchestrated by the vascular system, are unknown but not expected to predominate the fundamental osteogenic response.…”

Section: Discussionmentioning

confidence: 99%

“…Ex vivo bioreactor models provide an alternative to live animal testing for early development of implant fixation technology for applications where the interplay between cellular response and bone structure is important (Dua et al, 2021;Zankovic et al, 2021;Hall et al, 2023;Kohli et al, 2023). The model is an intermediate between in vitro studies of isolated biological processes and in vivo studies with many potentially confounding effects: it enables study under tightly controlled near-physiological conditions whilst preserving the inherent cellular diversity and extracellular structure of natural bone.…”

Section: Introductionmentioning

confidence: 99%

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Active osseointegration in an ex vivo porcine bone model

Hall,

Theodoridis,

Kohli

et al. 2024

Front. Bioeng. Biotechnol.

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Achieving osseointegration is a fundamental requirement for many orthopaedic, oral, and craniofacial implants. Osseointegration typically takes three to 6 months, during which time implants are at risk of loosening. The aim of this study was to investigate whether osseointegration could be actively enhanced by delivering controllable electromechanical stimuli to the periprosthetic bone. First, the osteoconductivity of the implant surface was confirmed using an in vitro culture with murine preosteoblasts. The effects of active treatment on osseointegration were then investigated in a 21-day ex vivo model with freshly harvested cancellous bone cylinders (n = 24; Ø10 mm × 5 mm) from distal porcine femora, with comparisons to specimens treated by a distant ultrasound source and static controls. Cell viability, proliferation and distribution was evident throughout culture. Superior ongrowth of tissue onto the titanium discs during culture was observed in the actively stimulated specimens, with evidence of ten-times increased mineralisation after 7 and 14 days of culture (p < 0.05) and 2.5 times increased expression of osteopontin (p < 0.005), an adhesive protein, at 21 days. Moreover, histological analyses revealed increased bone remodelling at the implant-bone interface in the actively stimulated specimens compared to the passive controls. Active osseointegration is an exciting new approach for accelerating bone growth into and around implants.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Active osseointegration in an ex vivo porcine bone model

Hall,

Theodoridis,

Kohli

et al. 2024

Front. Bioeng. Biotechnol.

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“…Similarly, Hall et al developed a composite out of two piezoelectrics 0.94Bi 0.5 Na 0.5 TiO 3 (BNT) and BaTiO 3 (BT). They reported cell viability >100% which results in cellular proliferation when cultured on murine preosteoblast cells (MC3T3-E1) . Leaving behind BT, a very promising piezoelectric K 0.5 Na 0.5 NbO 3 (KNN) is gaining prominence owing to its biocompatibility, enhanced cell proliferation, and excellent protein adsorption capability .…”

Section: Introductionmentioning

confidence: 99%

“…They reported cell viability >100% which results in cellular proliferation when cultured on murine preosteoblast cells (MC3T3-E1). 11 Leaving behind BT, a very promising piezoelectric K 0.5 Na 0.5 NbO 3 (KNN) is gaining prominence owing to its biocompatibility, enhanced cell proliferation, and excellent protein adsorption capability. 12 Adding KNN to HAP could be an exciting prospect, as preliminary reports on the ceramic composites are quite promising.…”

Section: ■ Introductionmentioning

confidence: 99%

Exploring Multifunctional Response of Ca₁₀(PO₄)₆(OH)₂–K_0.5Na_0.5NbO₃ Ceramic Composite for Biomedical Applications

Pandey,

Das,

Sharma

et al. 2023

ACS Biomater. Sci. Eng.

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This study focuses on investigating the intriguing properties of Ca 10 (PO 4 ) 6 (OH) 2 (HAP)−K 0.5 Na 0.5 NbO 3 (KNN) bioceramic composites, seeking to elucidate the relationship between their structural, electrical, biological, and optical behavior. The article begins with a close inspection of the O 1s spectra of the specimens obtained from X-ray photoelectron spectroscopy (XPS). The spectra reveal the peak related to lattice oxygen, O vacancy and the surface adsorbed O. The formed O vacancy strongly influences the changes in lattice parameters as observed from the X-ray diffraction (XRD) patterns. The frequency variation of the dielectric response for the composites in the radio frequency (RF) regime has electrical polarization effective for biomedical applications. Nyquist plots along with equivalent RC circuits further confirm that those electrical responses are mainly contributed from the grain boundaries. Adsorption dynamics of protein on the ceramic surface are investigated using bovine serum albumin (BSA), which established the major role of electrostatic interaction. Surface charge and O vacancies are modeled to understand the adsorption of protein and a linear correlation is reported. The role of O vacancies in modulating adsorption dynamics adds a new dimension to this study. The conformational change of BSA has also been considered by constructing the secondary structure following the protein-ceramic interaction. Excitingly, the composites are also found to be fluorescent active, a courtesy of the defects and vacancies leading to electron−hole recombination in the forbidden region. These promising properties envision an exciting future for HAP-KNN composites, especially in the domain of bioimaging and bone-tissue engineering.

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A brief study of electrical and biological properties of BNT6BT/ZnO-HA Composite

Fotoohi,

Hayati,

Mohassel

et al. 2024

Journal of Alloys and Compounds

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Electromechanical and biological evaluations of 0.94Bi0.5Na0.5TiO3–0.06BaTiO3 as a lead-free piezoceramic for implantable bioelectronics

Cited by 4 publications

References 68 publications

Active osseointegration in an ex vivo porcine bone model

Active osseointegration in an ex vivo porcine bone model

Exploring Multifunctional Response of Ca₁₀(PO₄)₆(OH)₂–K_0.5Na_0.5NbO₃ Ceramic Composite for Biomedical Applications

A brief study of electrical and biological properties of BNT6BT/ZnO-HA Composite

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Electromechanical and biological evaluations of 0.94Bi0.5Na0.5TiO3–0.06BaTiO3 as a lead-free piezoceramic for implantable bioelectronics

Cited by 4 publications

References 68 publications

Active osseointegration in an ex vivo porcine bone model

Active osseointegration in an ex vivo porcine bone model

Exploring Multifunctional Response of Ca10(PO4)6(OH)2–K0.5Na0.5NbO3 Ceramic Composite for Biomedical Applications

A brief study of electrical and biological properties of BNT6BT/ZnO-HA Composite

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Exploring Multifunctional Response of Ca₁₀(PO₄)₆(OH)₂–K_0.5Na_0.5NbO₃ Ceramic Composite for Biomedical Applications