Evaporation duct anomalies are always present above various oceanic processes, and their response to ubiquitous mesoscale eddies in the Kuroshio Extension region is quantitatively analyzed for the first time in this study using a synthetic analysis method based on reanalysis data sets and eddy trajectory data sets. The results indicated that the spatial distribution of evaporation duct anomalies is characterized by a monopole pattern, mainly modulated by the amplitude of anticyclonic eddies (AEs) and by the radius of cyclonic eddies (CEs). For AEs, the coupling strength is 0.7 m (2.9 M) per meter increase in amplitude, while for CEs, the coupling strength is 0.2 m (0.6 M) per 100 km increase in radius for the average evaporation duct height anomalies (evaporation duct strength anomalies) within the radius range. The modulation of evaporation duct anomalies by eddies is further examined.