“…In this regard, using microneedles (MNs) based sensors is an effective strategy to monitor the ISF analytes in a minimally invasive and rapid manner, without the need for expert personnel or using painful and complex devices [6] , [9] , [12] , [13] , [14] . Measuring biomarkers including electrolytes and pH, is crucial due to their role in metabolic processes including regulating nerves, kidneys, heart, and muscle cells [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] . pH was proven as a significant biomarker for monitoring health, given its impact on various biological processes.…”