Electrolytes in the Aging

Schlanger, Lynn E.; Bailey, James L.; Sands, Jeff M.

doi:10.1053/j.ackd.2010.03.008

Cited by 90 publications

(51 citation statements)

References 93 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…doubly labelled water) has not been measured to test the association between it and 24 h urinary K. The measurement of 24 h urinary K excretion has the advantage over other biochemical methods of being non-invasive and inexpensive. It should be noted, however, that K excretion via the urine varies depending on age, sex, the amount of physical activity undertaken and BMI (10,(43)(44)(45) , for which adjustment was made in the present study. Furthermore, it must be stated that using the 24 h urine method has some limitations.…”

Section: Discussionmentioning

confidence: 99%

Relationship between 24 h urinary potassium and diet quality in the adult Spanish population

Rodríguez-Rodríguez

Ortega

Carvajales

et al. 2014

Public Health Nutr.

View full text Add to dashboard Cite

Objective: To study the relationship between diet quality and 24 h urinary K excretion. Design: K was measured in 24 h urine samples, while diet was studied using a 24 h recall method over two consecutive days. Diet quality was determined using the Healthy Eating Index (HEI). The body weight, height and body composition of all participants were recorded, and the BMI of each calculated. Setting: Representative members of the adult Spanish population from the FANPE Study ('Fuentes Alimentarias de Nutrientes en Población Española'; Dietary Sources of Nutrients in the Spanish Population). Subjects: The final sample size was 329 participants aged 18-60 years. Results: Participants with a 24 h urinary K excretion ≥ 93 mmol/d (group AP = adequate potassium) had greater self-reported K intakes, consumed more fruit and vegetables, had a more varied diet and had better HEI scores than those with a 24 h urinary K excretion < 93 mmol/d (group IP = inadequate potassium). A significant positive correlation was seen between 24 h urinary K and dietary variety and the number of servings of fruits, vegetables and dairy products consumed, and between each of these and the HEI after correcting for age, sex, BMI, coefficient of activity, energy intake and the under-reporting of energy intake. AP participants were less likely to have an inadequate diet (HEI score < 50) than IP participants (OR = 0·439; 95 % CI 0·201, 0·961; P = 0·039). Conclusions: Diet quality, measured by the HEI, is correlated with 24 h urinary K excretion in Spanish adults.

show abstract

Section: Discussionmentioning

confidence: 99%

Relationship between 24 h urinary potassium and diet quality in the adult Spanish population

Rodríguez-Rodríguez

Ortega

Carvajales

et al. 2014

Public Health Nutr.

View full text Add to dashboard Cite

show abstract

“…The fi ndings also suggest that being dependent or less mobile contribute to hypernatraemia (only 22% of patients were living at home independently, whereas 64% were admitted from care homes) as does having dementia (53% of patients). Previous studies have shown that electrolyte imbalances are more prevalent in older people, 2,3,8 those living in institutions 9 and those with Alzheimer's dementia. 10 Only 12 of the 55 patients who were admitted lived independently at home.…”

Section: Discussionmentioning

confidence: 99%

“…This is most commonly seen in infants and in adults with impaired mental status, particularly older patients. 2,3 Older patients might also have a diminished thirst response to osmotic stimulation via an unknown mechanism. 4,5 Hypernatraemia is often poorly managed.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3] Having observed that patients presenting with hypernatraemia to the Frenchay Hospital, Bristol, tended to be older or from care homes, and that the management of these patients was inconsistent, I undertook this study to determine the types of patient who were being admitted with hypernatraemia, and whether their management was appropriate.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The management of patients presenting with hypernatraemia: is aggressive management appropriate?

Maggs

2014

Clinical Medicine

View full text Add to dashboard Cite

Hypernatraemia is a common fi nding among patients presenting to hospital. The aim of this observational study was to discover what types of patients presented with hypernatraemia and whether they were appropriately managed. The management of hypernatraemia was audited against common standards of care. Hypernatraemia at presentation carries a poor prognosis and in this study management of hypernatraemia was found to be done poorly, possibly because for many patients aggressive management was deemed inappropriate. The majority of patients who present with hypernatraemia are older, dependent and/or suffer from cognitive impairment. Many of these patients do not have a reversible cause for their hypernatraemia. These patients need to be recognised, ideally in the community, so that inappropriate admission can be avoided, but also on presentation to hospital so that appropriate care, which may be end-of-life care, can be provided.

show abstract

“…Hypokalemia is an important electrolyte disorder occasionally seen in elderly patients [1]. The serum potassium (K) level is determined mainly by the balance among oral intake, distribution, and excretion via the kidney and the gastrointestinal tract [2].…”

Section: Introductionmentioning

confidence: 99%

Severe metabolic alkalosis, hypokalemia, and respiratory acidosis induced by the Chinese herbal medicine yokukansan in an elderly patient with muscle weakness and drowsiness

et al. 2012

View full text Add to dashboard Cite

Yokukansan is a Chinese herbal medicine containing licorice that has been shown to alleviate the behavioral and psychological symptoms of Alzheimer's disease, with few adverse effects. Increasing numbers of patients with Alzheimer's disease in Japan are now being treated with this drug. However, yokukansan should be used with caution because of its potential to induce pseudoaldosteronism through the inhibition of 11-betahydroxysteroid dehydrogenase type 2, which metabolizes cortisol into cortisone. We present the case of an 88-yearold woman with a history of Alzheimer's disease who was transferred to our emergency department because of drowsiness, anorexia, and muscle weakness. Her blood pressure was 168/90 mmHg. Laboratory data showed serum potassium of 1.9 mmol/l, metabolic alkalosis (pH 7.54; HCO 3 -, 50.5 mmol/l; chloride, 81 mmol/l; sodium, 140 mmol/l), and respiratory disorders (pCO 2 , 60.5 mmHg; pO 2 , 63.8 mmHg). Plasma renin activity and aldosterone concentration were suppressed, and urinary potassium excretion was 22 mmol/l (calculated transtubular potassium gradient 12.9). An electrocardiogram showed flat T-waves and U-waves with ventricular premature contractions.Echocardiography denied volume depletion. Medical interview disclosed that she had been treated with a Chinese herbal medicine (yokukansan) containing licorice. The final diagnosis was pseudoaldosteronism and respiratory acidosis induced by licorice. Hypokalemia, metabolic alkalosis, and respiratory acidosis all subsided shortly after the discontinuation of yokukansan and initiation of intravenous potassium replacement. This case highlights the need for nephrologists to consider the possible involvement of Chinese herbal medicines, including yokukansan, when they encounter hypokalemia in elderly patients.

show abstract

Electrolytes in the Aging

Cited by 90 publications

References 93 publications

Relationship between 24 h urinary potassium and diet quality in the adult Spanish population

Relationship between 24 h urinary potassium and diet quality in the adult Spanish population

The management of patients presenting with hypernatraemia: is aggressive management appropriate?

Severe metabolic alkalosis, hypokalemia, and respiratory acidosis induced by the Chinese herbal medicine yokukansan in an elderly patient with muscle weakness and drowsiness

Contact Info

Product

Resources

About