Electrolytes in Denervated Muscle

Drahota, Z

doi:10.1007/978-1-4899-4854-0_7

Cited by 7 publications

(6 citation statements)

References 47 publications

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“…Total brain DNA content in infant and adult rats was in agreement with values reported by Winick (30). The present findings of higher quantitative cerebral uptake of D-8-hydroxybutyrate and acetoacetate per mg DNA by starving infant rats than by starving adult rats corresponds well with the in vitro findings of a higher capacity to utilize ketone bodies in infant than in adult rat brain (10,14,17,18,21). The mean rate of cerebral utilization of glucose was 0.44 Fmol/(g brain tissue x min) in adult rats, which was in reasonable agreement with that given by Hawkins et al (12) for pentobarbital-anesthetized adult rats.…”

Section: Discussionsupporting

confidence: 89%

“…I n vrtro studies have shown that when brain slices of 5-day-old rats were incubated with glucose or acetoacetate, the oxygen consumption increased equally with either substrate (10). Furthermore, the formation of acetyl-coenzyme A occurred more readily from acetoacetate or DL-j3-hydroxybutyrate than from glucose in cerebral cortex slices from infant rats.…”

Section: Speculationmentioning

confidence: 99%

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The Rate of Cerebral Utilization of Glucose, Ketone Bodies, and Oxygen: A Comparative in Vivo Study of Infant and Adult Rats

Dahlquist

Persson

1976

Pediatr Res

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Section: Discussionsupporting

confidence: 89%

Section: Speculationmentioning

confidence: 99%

The Rate of Cerebral Utilization of Glucose, Ketone Bodies, and Oxygen: A Comparative in Vivo Study of Infant and Adult Rats

Dahlquist

Persson

1976

Pediatr Res

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“…muscle (Table 1) Table 4 show a small increase in fibre sodium in denervated muscle, though these differences are not statistically significant. Drahota (1962) detected no change in fibre sodium in denervated rat muscle.…”

Section: Resultsmentioning

confidence: 79%

Sodium movements in denervated muscle and the effects of antimycin A

Creese¹,

El-Shafie²,

Vrbová³

1968

The Journal of Physiology

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SUMMARY1. Fibre sodium in rat diaphragm exchanged at a faster rate in muscles which had been denervated 8 days previously. The half-time was 3-7 min for outward movement in denervated muscles and 5*1 min in controls.2. The inward movement of sodium was also faster in denervated muscle as compared with controls, and the calculated permeability to sodium was approximately doubled.3. In the presence of antimycin A (1-8 x 10-5 M), the outward movement of sodium in denervated diaphragm was slowed and the fibres gained sodium and lost potassium.4. Antimycin markedly reduced the twitch produced by stimulation of denervated diaphragm, and also the response to acetylcholine. Similar effects were found in denervated tibialis anterior of the cat.

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“…The relatively minor increase in the inulin space following denervation suggests that extracellular space changes cannot account for most of the increased blood flow. Increased inulin space has been reported for the denervated tibialis anterior muscle ( 6).…”

Section: Resultsmentioning

confidence: 90%

The rate of nutrient supply to normal and denervated slow and fast muscle, and its relation to muscle blood flow

Bondy

Purdy

Carroll

et al. 1976

Experimental Neurology

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Muscle blood flow, glucose uptake, and the ability of muscle to concentrate an inert amino acid have been studied in vivo using a variety of radiosotopes. The rate of blood flow is four times greater in the slow soleus muscle than in the fast gastrocnemius muscle of the rat, but the rate of deoxyglucose uptake is 14 times higher in the slow muscle relative to the fast muscle. Slow muscle is also able to accumulate the inert amino acid, a-aminoisobutyric acid, more effectively than does fast muscle. A week after denervation, the rate of blood flow through denervated muscles was increased 30-to 40-fold over control values. However, deoxyglucose uptake was not significantly elevated in the gastrocnemius and was reduced to 20% of control levels in the so1eus. The ability of the denervated muscles to concentrate a-aminoisobutyric acid was also impaired. These changes could not be accounted for in terms of an altered inulin space. There is no correlation between the rate of muscle blood flow and the ability of muscle to extract blood-borne nutrients. Impaired transport mechanisms precede and may initiate the major morphological changes that follow muscle denervation.

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Electrolytes in Denervated Muscle

Cited by 7 publications

References 47 publications

The Rate of Cerebral Utilization of Glucose, Ketone Bodies, and Oxygen: A Comparative in Vivo Study of Infant and Adult Rats

The Rate of Cerebral Utilization of Glucose, Ketone Bodies, and Oxygen: A Comparative in Vivo Study of Infant and Adult Rats

Sodium movements in denervated muscle and the effects of antimycin A

The rate of nutrient supply to normal and denervated slow and fast muscle, and its relation to muscle blood flow

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