Electrolyte Imbalance and COVID-19 Severity in Hospitalized Patients

Miri, Maryam; Badriahmadi, Shaghayegh; Shamshirian, Ali; Ghalibaf, AmirAli Moodi; Mozdourian, Mahnaz

doi:10.5812/numonthly-128085

Cited by 2 publications

(3 citation statements)

References 19 publications

(34 reference statements)

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“…[47]. Severe COVID-19 patients had reduced calcium levels [35, 48]. Studies suggest electrolyte level abnormalities in Long-COVID patients, but electrolytes do not serve as severity markers in COVID-19 [49].…”

Section: Discussionmentioning

confidence: 99%

“…Studies suggest electrolyte level abnormalities in Long-COVID patients, but electrolytes do not serve as severity markers in COVID-19 [49]. Studies have shown that hypermagnesemia significantly indicates the severity and potential adverse outcomes of SARS-CoV-2 infections [35]. COVID-19 patients may experience electrolyte disturbances, including calcium [38].…”

Section: Discussionmentioning

confidence: 99%

“…COVID-19 patients with low serum albumin have worse results, including death [33], and predicting COVID-19 severity [34]. Serious COVID-19 is linked to serum electrolyte abnormalities [35, 36]. Drug side effects, fever, hyperventilation, perspiration, and nutrition may induce it [37].…”

Section: Introductionmentioning

confidence: 99%

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Correlation between Galanin and its receptor with the serum electrolytes in Long-COVID patients

Al Masoodi,

Radhi,

Abdalsada

et al. 2023

Preprint

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Background:Long-COVID is a complicated condition with prolonged SARS-CoV-2 symptoms. Several variables have been studied in this illness. Among the less studied variables are galanin and its receptor (GalR1). The Galanin system is involved in the pathophysiology of several age-related chronic disorders, including alcoholism, chronic pain, and bowel and skin inflammation. The aim of the study is to correlate the galanin system parameters with clinical and biochemical variables in Long-COVID.Methods:Serum levels of albumin, electrolytes, GAL, GALR1, and C-reactive protein (CRP) are measured by ELISA technique in 90 Long-COVID patients and 60 recovered subjects who are free from any symptoms of Long-COVID.Results:The study showed a significantly increased Galanin, GALR1, and the Gal/GALR1 ratio. On the contrary, serum albumin, total calcium, ionized calcium, total magnesium, and the ionized calcium/magnesium ratio were significantly decreased. Galanin and Galanin/GALR1 showed significant age-related associations (ρ=0.353, p<0.01) and (ρ=0.218, p<0.05), respectively. The lowest SpO2 was associated with Galanin (ρ=-0.295, p<0.01) and GALR1 (ρ=-0.232, p<0.05), respectively. According to ROC analysis results, the highest sensitivities for differentiating between patients and non-patient subjects were Galanin (71.7%) and GALR1 (60.0%).Conclusions:Galanin, GALR1, and Long-COVID disease are directly correlated. However, more research is needed to find out exactly what roles plasma Galanin and its receptor play in Long-COVID disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Correlation between Galanin and its receptor with the serum electrolytes in Long-COVID patients

Al Masoodi,

Radhi,

Abdalsada

et al. 2023

Preprint

View full text Add to dashboard Cite

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d-dimer as a biomarker for COVID-19-associated pulmonary thromboembolism: a narrative review from molecular pathways to the imaging findings

Beidollahkhani,

Fayedeh,

Shoja

et al. 2023

Egypt J Bronchol

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Background The coronavirus disease 2019, also known as COVID-19, imposed various challenges to healthcare and became a pandemic accompanied by a high rate of mortality. This infection has many manifestations and affects nearly all body systems. The circulatory and coagulation systems also seem to be affected. Studies show elevated rates of thrombotic events within COVID-19 patients such as disseminated intravascular coagulation (DIC), deep vein thrombosis (DVT), and pulmonary embolism (PE). Incidences of such coagulopathies were correlated to poor patient prognosis and mortality. Given the importance, complication, and mortality caused by thrombotic events (TEs) in COVID-19 patients, the goals of this study are to collect and analyze data on coagulopathy in COVID-19 patients and the pathophysiology and molecular events behind it. We also aim to bring attention to the role of d-dimer in COVID-19 infection by presenting the most recent information available from research studies evaluating d-dimer as a potential biomarker for disease severity, as well as mortality in COVID-19 patients. Main body Various mechanisms are described for COVID-19 coagulopathies such as endothelial cell dysfunction, fibrinolysis inhibitor overexpression, immuno-thrombosis, and imbalance between pro- and anticoagulants, to name a few. d-dimer which is a degradation product of fibrin is a helpful diagnostic tool for the assessment of clots and thrombosis. Given the pro-thrombotic nature of COVID-19 infection, within the current narrative review, we studied the diagnostic value of d-dimer for PE prediction. Several studies utilized d-dimer as a predictive tool for detecting PE, and the results were varied. Different cutoff points are proposed ranging from 0.5 up to over 4 mg/L with varying sensitivity and specificity. Although CT pulmonary angiography (CTPA) is the standard model for the prediction of PE, radiation exposure, contrast nephropathy, higher cost, and lack of adequate access can shift our diagnosis into models based on d-dimer. Short conclusion In summary, various coagulopathies have been associated with COVID-19 infection, and a safe and early diagnosis is needed. d-dimer showed various successes in PE prediction and can be a good candidate for further research and diagnostic model and algorithm development.

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Electrolyte Imbalance and COVID-19 Severity in Hospitalized Patients

Cited by 2 publications

References 19 publications

Correlation between Galanin and its receptor with the serum electrolytes in Long-COVID patients

Correlation between Galanin and its receptor with the serum electrolytes in Long-COVID patients

d-dimer as a biomarker for COVID-19-associated pulmonary thromboembolism: a narrative review from molecular pathways to the imaging findings

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