Electrolyte Balance in Uncontrolled and Controlled Diabetic Ketosis and Acidosis*

The Effect of Alloxan Diabetes and Acidosis on the Mineral and Water Content of Bone12

“…Depletion of the body stores of fixed base is the most serious complication of diabetic ketoacidosis, and losses of total body sodium of 25 to 50 per cent have been reported in diabetic acidosis in man (1)(2)(3)(4). Recent work from several laboratories has indicated that from 30 to 45 per cent of the total body sodium exists out of solution in the mineral solids of the skeleton (5)(6)(7).…”

“…The results indicated that untreated alloxan diabetes, in the absence of acidosis, as indicated by normal blood pH's, had no effect on bone sodium stores, and that both normal and diabetic animals responded to acidosis with a comparable decrease of about 12 per cent in bone crystal sodium content. 1 Supported by Public Health Service Grant A-525 and National Science Foundation Grant G-1307. 2 Presented in part before the Twentieth International…”