Electrolyte and pH-sensitive amphiphilic alginate: synthesis, self-assembly and controlled release of acetamiprid

Tang, Yi‐Yuan; Chen, Kai; Li, Jiacheng; Ye, Feng; Yu, Gaobo; Wang, Longzheng; Zhao, Xinyu; Yang, Peng; Zhang, Quan

doi:10.1039/c8ra05503c

Cited by 20 publications

(12 citation statements)

References 32 publications

(39 reference statements)

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“…In particular, SA can be modified by hydrophobic groups via Ugi reaction . The modified SA containing simultaneous hydrophilic and hydrophobic groups self-assembles in water to form micelles with hydrophilic shells and hydrophobic cavities, hydrophobic drugs such as acetamide can be held in the cavity …”

Section: Gel Methods Of Samentioning

confidence: 99%

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Recent Development of Alginate-Based Materials and Their Versatile Functions in Biomedicine, Flexible Electronics, and Environmental Uses

Teng

Chen

et al. 2021

ACS Biomater. Sci. Eng.

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Alginate is a natural polysaccharide that is easily chemically modified or compounded with other components for various types of functionalities. The alginate derivatives are appealing not only because they are biocompatible so that they can be used in biomedicine or tissue engineering but also because of the prospering bioelectronics that require various biomaterials to interface between human tissues and electronics or to serve as electronic components themselves. The study of alginate-based materials, especially hydrogels, have repeatedly found new frontiers over recent years. In this Review, we document the basic properties of alginate, their chemical modification strategies, and the recent development of alginate-based functional composite materials. The newly thrived functions such as ionically conductive hydrogel or 3D or 4D cell culturing matrix are emphasized among other appealing potential applications. We expect that the documentation of relevant information will stimulate scientific efforts to further develop biocompatible electronics or smart materials and to help the research domain better address the medicine, energy, and environmental challenges faced by human societies.

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Section: Gel Methods Of Samentioning

confidence: 99%

“…147 The modified SA containing simultaneous hydrophilic and hydrophobic groups self-assembles in water to form micelles with hydrophilic shells and hydrophobic cavities, 148 hydrophobic drugs such as acetamide can be held in the cavity. 149 4.1.4. Double Network Cross-Linking.…”

Section: Functional Modification Of Samentioning

confidence: 99%

Recent Development of Alginate-Based Materials and Their Versatile Functions in Biomedicine, Flexible Electronics, and Environmental Uses

Teng

Chen

et al. 2021

ACS Biomater. Sci. Eng.

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“…The average diameters of these spherical micelles increased from 1 to 5 μm with increasing the copolymer concentration, whereas an almost constant ZP value of −82.85 mV was noticed independent of the copolymer concentration. Another hydrophobically modified and pH-responsive amphiphilic alginate copolymer was synthesized via Ugi reaction and used for the preparation of drug-loaded micelles by direct dissolution [ 72 ]. The impact of Na + concentration on the micellar sizes was studied, and it appeared that the decrease of the ionic strength led to an increase of the average micellar diameters.…”

Section: Micellar Drug Delivery Systems Based On Polysaccharidesmentioning

confidence: 99%

Micellar Drug Delivery Systems Based on Natural Biopolymers

Atanase

2021

Polymers

147

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The broad diversity of structures and the presence of numerous functional groups available for chemical modifications represent an enormous advantage for the development of safe, non-toxic, and cost-effective micellar drug delivery systems (DDS) based on natural biopolymers, such as polysaccharides, proteins, and peptides. Different drug-loading methods are used for the preparation of these micellar systems, but it appeared that dialysis is generally recommended, as it avoids the formation of large micellar aggregates. Moreover, the preparation method has an important influence on micellar size, morphology, and drug loading efficiency. The small size allows the passive accumulation of these micellar systems via the permeability and retention effect. Natural biopolymer-based micellar DDS are high-value biomaterials characterized by good compatibility, biodegradability, long blood circulation time, non-toxicity, non-immunogenicity, and high drug loading, and they are biodegraded to non-toxic products that are easily assimilated by the human body. Even if some recent studies reported better antitumoral effects for the micellar DDS based on polysaccharides than for commercial formulations, their clinical use is not yet generalized. This review is focused on the studies from the last decade concerning the preparation as well as the colloidal and biological characterization of micellar DDS based on natural biopolymers.

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“…The labeled fluorescein could potentially be used for fluorescent imaging. Using a similar strategy, a pH‐responsive amphiphilic alginate was also elaborated 61 . The produced polymer could form nanoassemblies in aqueous solution with tunable sizes by varying pH and Na + concentration.…”

Section: Polymers From Multicomponent Polymerizations and Their Self‐...mentioning

confidence: 99%

“…Using a similar strategy, a pH-responsive amphiphilic alginate was also elaborated. 61 The produced polymer could form nanoassemblies in aqueous solution with tunable sizes by varying pH and Na + concentration. They were also evaluated as drug delivery systems, the release kinetics of which were affected by both pH and ion concentration in the system.…”

Section: Polymers From Ugi Reactionmentioning

confidence: 99%

Self‐assembly of polymers from multicomponent reactions

Liu

Kanjilal

Thayumanavan

2022

Polymer International

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Supramolecular assemblies from synthetic polymers have been widely used in materials science and biological applications. Developing convenient and efficient methods to tune polymer structures and architectures is important for achieving desired self‐assembly behaviors. Among various synthetic strategies, multicomponent reactions have drawn significant interest due to the high reaction efficiency, chemical selectivity, atom economy and one‐pot manner. These features make it convenient to manipulate polymer properties by varying chemical building blocks. In this review, we summarize the recent advances in the self‐assembly of polymers from multicomponent reactions. We discuss how multicomponent reactions are applied for polymerization and post‐polymerization modifications, generating polymers with specific self‐assembly behaviors for various research and application purposes. Challenges and perspectives about the development of this field are also discussed. © 2021 Society of Industrial Chemistry.

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Electrolyte and pH-sensitive amphiphilic alginate: synthesis, self-assembly and controlled release of acetamiprid

Abstract: Schematic of Ugi-Alg aggregation in aqueous solution of different NaCl concentrations and pH values.

Cited by 20 publications

References 32 publications

Recent Development of Alginate-Based Materials and Their Versatile Functions in Biomedicine, Flexible Electronics, and Environmental Uses

Recent Development of Alginate-Based Materials and Their Versatile Functions in Biomedicine, Flexible Electronics, and Environmental Uses

Micellar Drug Delivery Systems Based on Natural Biopolymers

Self‐assembly of polymers from multicomponent reactions

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