Electrolyte abnormalities in patients hospitalized with COVID-19

Abate, Mersema; Andrade, Hugo Paz; Barnett, Richard; Bellucci, Alessandro; Bhaskaran, Madhu; Corona, A.; Chang, Bessy Suyin Flores; Finger, Mark; Fishbane, Steven; Gitman, Michael; Halinski, Candice; Hasan, Shamir; Hazzan, Azzour D.; Hirsch, Jamie S.; Hong, Susana; Jhaveri, Kenar D.; Khanin, Yuriy; Kuan, Aireen; Madireddy, Varun; Malieckal, Deepa; Muzib, Abdulrahman; Nair, Gayatri; Nair, Vinay; Ng, Jia H.; Parikh, Rushang; Ross, Daniel W.; Sakhiya, Vipulbhai; Sachdeva, Mala; Schwarz, Richard P.; Shah, Hitesh; Sharma, Purva; Singhal, Pravin C.; Uppal, Nupur N.; Wanchoo, Rimda

doi:10.1093/ckj/sfab060

Cited by 27 publications

(18 citation statements)

References 4 publications

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“…This longitudinal retrospective cohort of 414 hospitalised patients with a diagnosis of COVID-19 demonstrates a high incidence of hyponatraemia < 135 mmol/l at hospital admission of 21.98%, with mild hyponatraemia being the most frequent in 81% of cases, which coincides with data published by other cohorts 8 , 9 , 21 , 22 , 23 , such as the Health Outcome Predictive Evaluation for COVID-19 (HOPE-COVID-19) study, a multicentre study of 37 hospitals in 7 countries, with Spanish collaboration, where 25% of patients hospitalised for COVID-19 had hyponatraemia 10 . Tzoulis et al 23 recently published a retrospective study of 488 hospitalised COVID-19 patients, mean age 68 years, from 2 London hospitals between February and May 2020; hyponatraemia at admission was 24.6%, coinciding with our data.…”

Section: Discussionsupporting

confidence: 88%

The impact of the correction of hyponatremia during hospital admission on the prognosis of SARS-CoV-2 infection

Flor

Gómez-Berrocal

Marschall

et al. 2022

Medicina Clínica (English Edition)

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Section: Discussionsupporting

confidence: 88%

The impact of the correction of hyponatremia during hospital admission on the prognosis of SARS-CoV-2 infection

Flor

Gómez-Berrocal

Marschall

et al. 2022

Medicina Clínica (English Edition)

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“… 433 – 436 Most hospitalized patients (91.1%) are diagnosed with pneumonia by physicians on hospital admission, with a mean incubation of 3 days after onset of symptoms, and 3.4–8% of hospitalized patients developed ARDS (acute respiratory distress syndrome 426 ). Extrapulmonary complications were observed in different organs and systems, including myocarditis, 437 – 439 arrhythmia, 440 – 442 myocardial ischemia 443 – 445 regarding the cardiovascular system, acute kidney injury 446 – 448 and electrolyte abnormalities, 449 – 451 hyperglycemia, 452 and ketoacidosis 453 in the urinary system, endocrine system, stroke, 454 – 456 and encephalitis 423 , 457 , 458 regarding the neurological system (Fig. 12 ).…”

Section: Molecular Characteristics Of Sequence and The Encoded Protei...mentioning

confidence: 99%

Molecular characteristics, immune evasion, and impact of SARS-CoV-2 variants

Sun

Xie

et al. 2022

Sig Transduct Target Ther

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The persistent COVID-19 pandemic since 2020 has brought an enormous public health burden to the global society and is accompanied by various evolution of the virus genome. The consistently emerging SARS-CoV-2 variants harboring critical mutations impact the molecular characteristics of viral proteins and display heterogeneous behaviors in immune evasion, transmissibility, and the clinical manifestation during infection, which differ each strain and endow them with distinguished features during populational spread. Several SARS-CoV-2 variants, identified as Variants of Concern (VOC) by the World Health Organization, challenged global efforts on COVID-19 control due to the rapid worldwide spread and enhanced immune evasion from current antibodies and vaccines. Moreover, the recent Omicron variant even exacerbated the global anxiety in the continuous pandemic. Its significant evasion from current medical treatment and disease control even highlights the necessity of combinatory investigation of the mutational pattern and influence of the mutations on viral dynamics against populational immunity, which would greatly facilitate drug and vaccine development and benefit the global public health policymaking. Hence in this review, we summarized the molecular characteristics, immune evasion, and impacts of the SARS-CoV-2 variants and focused on the parallel comparison of different variants in mutational profile, transmissibility and tropism alteration, treatment effectiveness, and clinical manifestations, in order to provide a comprehensive landscape for SARS-CoV-2 variant research.

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“… 221 , 223 , 259 Hyponatremia, hypochloremia, hypocalcemia, and acidosis are common electrolyte abnormalities associated with the high cell turnover seen in COVID-19 patients with acute kidney injury. 260 , 261 Direct SARS-CoV-2 infection of kidney cells has been reported using in vitro and post-mortem studies and may also contribute to local inflammation and kidney damage. 262 − 264 …”

Section: Pathophysiologymentioning

confidence: 99%

Two Years into the COVID-19 Pandemic: Lessons Learned

et al. 2022

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and virulent human-infecting coronavirus that emerged in late December 2019 in Wuhan, China, causing a respiratory disease called coronavirus disease 2019 (COVID-19), which has massively impacted global public health and caused widespread disruption to daily life. The crisis caused by COVID-19 has mobilized scientists and public health authorities across the world to rapidly improve our knowledge about this devastating disease, shedding light on its management and control, and spawned the development of new countermeasures. Here we provide an overview of the state of the art of knowledge gained in the last 2 years about the virus and COVID-19, including its origin and natural reservoir hosts, viral etiology, epidemiology, modes of transmission, clinical manifestations, pathophysiology, diagnosis, treatment, prevention, emerging variants, and vaccines, highlighting important differences from previously known highly pathogenic coronaviruses. We also discuss selected key discoveries from each topic and underline the gaps of knowledge for future investigations.

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Electrolyte abnormalities in patients hospitalized with COVID-19

Cited by 27 publications

References 4 publications

The impact of the correction of hyponatremia during hospital admission on the prognosis of SARS-CoV-2 infection

The impact of the correction of hyponatremia during hospital admission on the prognosis of SARS-CoV-2 infection

Molecular characteristics, immune evasion, and impact of SARS-CoV-2 variants

Two Years into the COVID-19 Pandemic: Lessons Learned

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