Electrokinetic transport properties of deoxynucleotide monophosphates (dNMPs) through α-phase phosphorene carbide nanochannel for electrophoretic detection

Abstract

Electrokinetic identification of biomolecules is an effective analytical method where electric field drives nucleic acid, peptides, and other species transporting through a nanoscale channel and the time of flight (TOF)...

A Portable Device for in Situ Noninvasive Monitoring of Cell Secretions and Communications with Fluorescence and Nanochannel Electrochemistry

“…Traditional proteomic analysis, such as enzyme-linked immunosorbent assay (ELISA) and mass spectrometry (MS), has been widely employed to detect cell secretions, while tedious preprocessing steps were needed, including extracting and collecting targets from cells, which will consume a large number of samples and contaminate samples. − In recent years, the utilization of micro/nanofluidic platforms has opened up unparalleled possibilities for conducting in situ analysis of cell secretion. , These platforms offer numerous advantages, including miniaturization, seamless integration, minimal sample usage, and swift analysis. − Lin’s group developed an open-space microfluidic chip, integrating cell culture and online semiquantitative detection of vascular endothelial growth factor (VEGF) via rolling circle amplification (RCA) reaction . Liu’s group designed a droplet sensor with Au nanoclusters as a signal amplifier to quantify extracellular H 2 O 2 secreted by different cell types at the single-cell level .…”