Electrokinetic chromatographic characterization of novel pseudo‐phases based on N‐alkyl‐N‐methylpyrrolidinium ionic liquid type surfactants

Schnee, Vincent P.; Baker, Gary A.; Rauk, Erika; Palmer, Christopher P.

doi:10.1002/elps.200600268

Cited by 36 publications

(18 citation statements)

References 48 publications

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“…Our group had previously reported results for C 16 MPYB, one of the surfactants in the cyclic head group series, and found that it provided significantly different chemical selectivity from C 16 TMAB [21]. The current results confirm that significant differences in selectivity exist between linear head group and analogous cyclic head group structures.…”

Section: Resultssupporting

confidence: 92%

“…The solvation parameter results for C 16 TMAB reported here differ from previously reported values [21,34]. Differences are most likely due the differences in buffer chemistry and concentration.…”

Section: Resultscontrasting

confidence: 82%

“…A collective comparison of EKC PSPs shows that cationic surfactants provide significantly different selectivity than other PSPs [20]. However, relatively few cationic surfactants have been studied compared to anionic surfactants.In a previous study, we have shown that micelles of two cationic surfactants with a relatively minor structural difference at the head group generate significantly different EKC separation selectivity [21]. Cationic surfactants offer a unique synthetic flexibility that allows systematic changes in the head group of the surfactant.…”

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confidence: 99%

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Cationic surfactants for micellar electrokinetic chromatography: 1. Characterization of selectivity using the linear solvation energy relationships model

Schnee

Palmer

2008

Electrophoresis

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MEKC and the linear solvation energy relationship (LSER) model have been applied to two series of cationic surfactants. The synthetic flexibility of the quaternary ammonium group is exploited to generate the two series, one consisting of linear substitutions and the other incorporating the ammonium into ring structures of varying size. The effects of the head group structure on the CMC, aggregation number, and electrophoretic properties of the surfactants were determined. These surfactants were also characterized with the LSER model, which allowed the contributions of five chemical factors to the interactions between solutes and the micelles to be evaluated. Trends were observed in the cohesivity and polarity of the linear surfactant series, with both increasing with the size of the head group. No trends in the LSER parameters were observed in the cyclic series, but the LSER results do show that the surfactants with cyclic head groups provide a significantly different solvation environment from the linear series. Additional trends were observed in the aggregation behavior and chromatographic properties of the surfactants. These included changes in the CMCs, aggregation numbers, EOF, and electrophoretic mobility of the micelles that correlate to changes in head group size.

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Section: Resultssupporting

confidence: 92%

Section: Resultscontrasting

confidence: 82%

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confidence: 99%

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Cationic surfactants for micellar electrokinetic chromatography: 1. Characterization of selectivity using the linear solvation energy relationships model

Schnee

Palmer

2008

Electrophoresis

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“…As a result, many materials have been introduced and studied as potentially useful PSPs. Micellar PSPs of a variety of surfactants have been shown to provide good performance and varied separation selectivity [11][12][13][14][15][16][17][18][19][20][21][22][23][24]. Extensive studies have shown that polymeric PSPs can offer significant performance advantages and selectivity differences relative to micellar PSPs [25][26][27][28][29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Retention behavior and selectivity of a latex nanoparticle pseudostationary phase for electrokinetic chromatography

et al. 2011

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The retention characteristics and separation selectivity of a novel latex nanoparticle (NP) pseudostationary phase (PSP) for electrokinetic chromatography have been characterized. The anionic NPs have very low or no affinity for cationic solutes, but show significant interactions and retention based on hydrophobic interactions. Retention factors of alkyl-phenyl ketones increase linearly with the concentration of the NPs and have zero or near zero y-intercepts as expected for electrokinetic chromatography with non-micellar PSPs. The retention factors of these solutes and representative pharmaceuticals decrease logarithmically with increases in the concentration of ACN in the background electrolyte, as expected for reversed-phase retention. Linear solvation energy relationship analysis indicates that the NPs are less cohesive than would be expected for polymeric PSPs with similar structure but that the overall separation selectivity can be expected to be similar to polymer PSPs with similar backbone chemistry. The results indicate that the hydrophobic core of the NPs is non-cohesive and is highly accessible to solutes, whereas the ionic head groups are not as accessible and do not contribute substantially to retention or selectivity.

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“…As the additives in EKC, some surfactants of RTILs were applied to achiral and chiral separation of binaphthyl derivatives [23] and determine bioactive flavonoids [29]. Several novel chiral ionic liquids were synthesized for micellar elctrokinetic chromatography to improve the separation [24][25][26]. As the main running electrolytes in CE, RTILs also embodied their special property in EOF and resolution [30,31].…”

Section: Introductionmentioning

confidence: 99%

Property of ionic liquid in electrophoresis and its application in chiral separation on microchips

Zeng¹,

Shen²,

Nakagama³

et al. 2007

Electrophoresis

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The aqueous solution of a kind of room-temperature ionic liquids (RTILs), 1-ethyl-3-methylimidazolium-tetrafluoroborate (1E-3MI-TFB), demonstrated its exclusive electroosmotic property in microchip electrophoresis. It was applied as the working electrolyte for chiral separation in glass microchip electrophoresis. Compared with boric acid buffer, 1E-3MI-TFB aqueous solution exhibited a broader separation window for enantiomers of dipeptides. Then the influences of chiral selector, pH and concentration on efficiency of chiral separation were discussed in detail. The unique mechanism of the generation of EOF was explored in a glass microchannel using 1E-3MI-TFB aqueous solution as working electrolyte. A possible status of 1E-3MI cation in water was suggested at the first time, which facilitated the explanation of EOF and its characteristics in glass microchannel. Additionally, microchip electrophoresis using 1E-3MI-TFB aqueous solution was successfully applied to the chiral separation of complex enantiomers of dipeptides. RTILs aqueous solution, as the electrolyte for the separation of complicated optical isomers, could lead to a revolution in the analytical methods of chiral or conformational analysis for biomolecules.

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Electrokinetic chromatographic characterization of novel pseudo‐phases based on N‐alkyl‐N‐methylpyrrolidinium ionic liquid type surfactants

Cited by 36 publications

References 48 publications

Cationic surfactants for micellar electrokinetic chromatography: 1. Characterization of selectivity using the linear solvation energy relationships model

Cationic surfactants for micellar electrokinetic chromatography: 1. Characterization of selectivity using the linear solvation energy relationships model

Retention behavior and selectivity of a latex nanoparticle pseudostationary phase for electrokinetic chromatography

Property of ionic liquid in electrophoresis and its application in chiral separation on microchips

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