Electrographic, clinical and pathological alterations following systemic administration of kainic acid, bicuculline or pentetrazole: Metabolic mapping using the deoxyglucose method with special reference to the pathology of epilepsy

Ben‐Ari, Yehezkel; Tremblay, E.; Riché, D.; Ghilini, Ginette; Naquet, R

doi:10.1016/0306-4522(81)90193-7

Cited by 618 publications

(225 citation statements)

References 57 publications

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“…In addition, we confirmed the findings of others that the entire SNR was metabolically active during the ictal period (Ben-Ari et al, 1981;Engel et al, 1978;Nehlig et al, 1992;Pazdernik et al, 1985). We also investigated the possibility that GPe and GPi (endopeduncular nucleus) act differentially because they may have opposing effects on movement (DeLong, 1990;Gerfen et al, 1990).…”

Section: Discussionsupporting

confidence: 86%

Regional neural activity within the substantia nigra during peri-ictal flurothyl generalized seizure stages

Velı́šková

Miller

Nunes

et al. 2005

Neurobiology of Disease

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Structures responsible for the onset, propagation, and cessation of generalized seizures are not known. Lesion and microinfusion studies suggest that the substantia nigra pars reticulata (SNR) seizurecontrolling network could play a key role. However, the expression of neural activity within the SNR and its targets during discrete pre-and postictal periods has not been investigated. In rats, we used flurothyl to induce generalized seizures over a controlled time period and 2-deoxyglucose autoradiography mapping technique. Changes in neural activity within the SNR were region-specific. The SNR posterior was selectively active during the pre-clonic period and may represent an early gateway to seizure propagation. The SNR anterior and superior colliculus changed their activity during progression to tonic-clonic seizure, suggesting the involvement in coordinated regional activity that results in inhibitory effects on seizures. The postictal suppression state was correlated with changes in the SNR projection targets, specifically the pedunculopontine tegmental nucleus and superior colliculus.

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Section: Discussionsupporting

confidence: 86%

Regional neural activity within the substantia nigra during peri-ictal flurothyl generalized seizure stages

Velı́šková

Miller

Nunes

et al. 2005

Neurobiology of Disease

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“…The behavioral effects induced by systemic administration of KA varied with the postnatal age, as previously described (Ben-Ari et al, 1981;Tremblay et al, 1984). Thus, in P10 animals scratchinglike movements appeared after 20 -25 min of KA injection, rapidly followed by tonicoclonic seizures.…”

Section: Seizures In Developing and Adult Ratssupporting

confidence: 52%

Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) Is Differentially Induced in Neurons and Astrocytes after Seizures: Evidence for Developmental, Immediate Early Gene, and Lesion Response

et al. 1997

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We investigated in vivo the expression of the tissue inhibitor of metalloproteinases-1 (TIMP-1) in the rat CNS after kainate (KA)-induced excitotoxic seizures. In situ hybridization revealed that TIMP-1 mRNA is induced rapidly and massively in most regions of the adult forebrain after KA treatment. Neuronal activity seems to be necessary but not sufficient to trigger TIMP-1 induction, because it is not observed in seizing 10-d-old pups, unlike what is observed in 21-and 35-d-old animals after seizures. The rapid induction of TIMP-1 is not prevented by the inhibitor of protein synthesis cycloheximide, suggesting that, after seizures, TIMP-1 is induced in neurons as an immediate early gene (IEG). The initial neuronal upregulation is followed by enhanced expression in astrocytes, as assessed by double-labeling experiments. In the hippocampus rapid increases in mRNA are followed by relatively delayed (8 hr after KA) increases in TIMP-1 immunoreactivity in the perisomatic and dendro-axonic areas, suggesting secretion of the protein. At 3 d after KA treatment, strong immunoreactivity is found in astrocytes and in the cell bodies and dendro-axonic projections of resistant neurons such as the dentate granule cells. Taken together, the results suggest that TIMP-1 may be instrumental for neurons and astrocytes in coupling early cellular events triggered by seizures with the regulation of long-lasting changes involved in tissue reorganization and/or neuroprotection.

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“…These regions are the same as those involved in the generation of paroxysmal activity produced by kainate (28). In addition, these regions previously showed significant changes in 2-deoxyglucose consumption after kainate administration (29).…”

Section: Discussionmentioning

confidence: 60%

Visualization of functionally activated circuitry in the brain

Wilson

Nag

Davern

et al. 2002

Proc. Natl. Acad. Sci. U.S.A.

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Electrographic, clinical and pathological alterations following systemic administration of kainic acid, bicuculline or pentetrazole: Metabolic mapping using the deoxyglucose method with special reference to the pathology of epilepsy

Cited by 618 publications

References 57 publications

Regional neural activity within the substantia nigra during peri-ictal flurothyl generalized seizure stages

Regional neural activity within the substantia nigra during peri-ictal flurothyl generalized seizure stages

Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) Is Differentially Induced in Neurons and Astrocytes after Seizures: Evidence for Developmental, Immediate Early Gene, and Lesion Response

Visualization of functionally activated circuitry in the brain

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