Electrographic analysis of the sleep cycle in young depressed patients

Taub, John M.; Hawkins, David R.; Castle, Robert

doi:10.1016/0301-0511(78)90013-3

Cited by 34 publications

(10 citation statements)

References 31 publications

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“…29 In depressed children and adolescents, no sleep EEG changes were found in comparison to age-matched healthy controls in most studies. [30][31][32] In contrast, other studies reported similar changes in depressed adults, children, and adolescents. 26,33,34 Kupfer and Foster submitted the hypothesis that a shortened REM latency is a specific marker of depression.…”

Section: Controlsmentioning

confidence: 83%

Sleep electroencephalography as a biomarker in depression

Steiger¹,

Pawlowski²,

Kimura³

2015

CPT

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Abstract:The sleep electroencephalogram (EEG) provides biomarkers of depression, which may help with diagnosis, prediction of therapy response, and prognosis in the treatment of depression. In patients with depression, characteristic sleep EEG changes include impaired sleep continuity, disinhibition of rapid-eye-movement (REM) sleep, and impaired non-REM sleep. Most antidepressants suppress REM sleep in depressed patients, healthy volunteers, and in animal models. REM suppression appears to be an important, but not an absolute requirement, for antidepressive effects of a substance. Enhanced REM density, a measure for frequency of REM, characterizes high-risk probands for affective disorders. REM-sleep changes were also found in animal models of depression. Sleep-EEG variables were shown to predict the response to treatment with antidepressants. Furthermore, certain clusters of sleep EEG variables predicted the course of the disorder for several years. Some of the predicted sleep EEG markers appear to be related to hypothalamic-pituitary-adrenal system activity.

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Section: Controlsmentioning

confidence: 83%

Sleep electroencephalography as a biomarker in depression

Steiger¹,

Pawlowski²,

Kimura³

2015

CPT

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“…These data support the assumption of a disturbance of the REM sleep regulating system during depression. If this does not become manifest during baseline sleep, as is true in young depressives (Taub et al, 1978;Hawkins et al, 1985;Cashman et al, 1986;Goetz et al, 1987;Hudson et al, 1987;Lauer et al, 1987) then it can be demasked by a cholinergic agent. In the present sample of patients with eating disorders, only one bulimic patient without a concomit-ant diagnosis of a major depression had a REM latency < 25 min during the drug night.…”

Section: Eating Disorders Controlsmentioning

confidence: 99%

EEG sleep and the cholinergic REM induction test in anorexic and bulimic patients

Lauer

Zulley

Krieg

et al. 1988

Psychiatry Research

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Abstract. The electroencephalographic (EEG) sleep of 20 anorexic patients, 10 bulimic patients, and 10 age-matched healthy controls was studied. In addition, six anorexic patients and six bulimic patients had a cholinergic rapid eye movement (REM) sleep induction test (RIT) performed with the cholinergic agent RS 86. The three samples showed no major differences in sleep patterns. The same held true when attention was focused on patients who additionally met D&U-Illcriteria for major depression. The RIT results were similar in the patients with eating disorders and in controls, but differed from those reported in depressives. Therefore, the present study found no hints of depression-like sleep patterns in patients with eating disorders.

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“…n support of h s latter consideration, several studies of younger outpatients with moderately severe depression have failed to find elevated rates of DST nonsuppression (Winokur et al, 1982;Jaffe et al, 1983) or shortened REM latencies (Taub et al, 1978;Hawbns et al, 1985;Cashman et al, 1986). In short, it appears that these markers may be less robust in younger outpatients with moderate degrees of major depression than in older inpatients with severe affective symptoms.…”

Section: Jmentioning

confidence: 97%

Urinary free cortisol and response to the dexamethasone suppression test in bulimia: A pilot study

Hudson

Katz

Pope

et al. 1987

Int. J. Eat. Disord.

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Previous studies have reported that patients with bulimia often display nonsuppressed responses to the dexamethasone suppression test (DST), suggesting that bulimia may be associated with hypercortisolism. To further evaluate the hypothalamic‐pituitary‐adrenal axis in bulimia, 24‐hour urinary free cortisol (UFC) levels and response to the 1 mg dexamethasone suppression test (DST) were assessed in 7 normal‐weight women with bulimia by DSM‐III criteria. All subjects displayed normal UFC levels and nonsuppressed responses to the DST.

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Electrographic analysis of the sleep cycle in young depressed patients

Cited by 34 publications

References 31 publications

Sleep electroencephalography as a biomarker in depression

Sleep electroencephalography as a biomarker in depression

EEG sleep and the cholinergic REM induction test in anorexic and bulimic patients

Urinary free cortisol and response to the dexamethasone suppression test in bulimia: A pilot study

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