Electroencephalographic study of the short-acting hypnotics etomidate and methohexital in dogs

Effects of morphine, fentanyl, sufentanil, and the short‐acting morphine‐like analgesic alfentanil on the EEG in dogs

“…Computer techniques have been developed and are used to analyze drug effects on sleepiwakefulness in animals [Gilden and Kazakiewicz, 1976;Tortella et at., 1978;Wauquier et al, 1978b;Young et al, 19781 andman[Saletu, 19761. Thesetechniques allow well-defined quantification and statistical analysis.…”

Synthesis, characterization, and crystal structure analysis of 2-(2-hydroxy-3-methoxyphenyl)-1-(4-chlorophenyl)-4,5-diphenyl-1h-imidazole

“…The imidazole ring system is the most important substructures found in a large number of natural products and pharmacologically active compounds [1]. For example, the amino acid histidine, the hypnotic agent etomidate [2], the antiulcerative agent cimetidine [3], the proton pump inhibitor omeprazole [4], the fungicide ketoconazole [5], and the benzodiazepine antagonist flumazenil [6] are imidazole derivatives. The potency and wide applicability of the imidazole pharmacophore can be attributed to its hydrogen bond donor-acceptor capability as well as its high affinity for metals, which are present in many protein active sites [7].…”

Ceric ammonium nitrate catalysed three component one-pot efficient synthesis of 2,4,5-triaryl-1H-imidazoles

“…The imidazole ring system is one of the most important substructures found in a large number of natural products and pharmacologically active compounds. [1][2][3][4][5] In recent years, substituted imidazoles are substantially used in ionic liquids, 6 that has been given a new approach to 'Green Chemistry'. Triarylimidazole derivatives have many biological activities, for example, herbicidal, 7 fungicidal, 8 antiinflammatory, 9 and antithrombotic activities.…”