Electroencephalographic sleep abnormalities in schizophrenia: Relationship to positive/negative symptoms and ventricular size

Tandon, Rajiv; Shipley, James E.; DeQuardo, John R.; Greden, John F.

doi:10.1016/0006-3223(89)91851-9

Cited by 15 publications

(30 citation statements)

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“…Global symptom severity is associated with increased waking, reduced REM sleep time, SWS deficits, and short REML [20,21,29]. Studies find that prolonged SL [30], impaired SE [31], short REML [13,21,24,32], and increased REM sleep EM density [16,17] correlate with positive symptoms, one constituent of global severity.…”

Section: Clinical and Neuropsychologic Correlations Clinical Correlatesmentioning

confidence: 94%

“…SWS deficits would permit the passive advance of the first REM period, producing a shorted REML. SWS deficits or stage 4 deficits frequently, but not consistently, are observed in PSG recordings of patients who are schizophrenic [13][14][15][18][19][20][21][22][24][25][26][27]. Although it is suggested that prior exposure to or withdrawal from APs might explain this inconsistency, stage 4 deficits are observed in first-episode, neuroleptic-naive schizophrenics [24].…”

Section: Objective Assessmentmentioning

confidence: 97%

“…Studies find that prolonged SL [30], impaired SE [31], short REML [13,21,24,32], and increased REM sleep EM density [16,17] correlate with positive symptoms, one constituent of global severity. Positive symptoms also are associated with EEG high frequency activity during the sleep of schizophrenics [33].…”

Section: Clinical and Neuropsychologic Correlations Clinical Correlatesmentioning

confidence: 97%

“…Many studies have examined this issue [13,14,16,[18][19][20][21][22][23][24], and the majority report significantly shorter REMLs in schizophrenics relative to healthy controls. Heterogeneity between patient samples and methodologic differences, including prior exposure to AP treatment, may explain the lack of consistency among these findings.…”

Section: Objective Assessmentmentioning

confidence: 99%

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Sleep in Schizophrenia: Impairments, Correlates, and Treatment

Benson¹

2006

Psychiatric Clinics of North America

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Section: Clinical and Neuropsychologic Correlations Clinical Correlatesmentioning

confidence: 94%

Section: Objective Assessmentmentioning

confidence: 97%

Section: Clinical and Neuropsychologic Correlations Clinical Correlatesmentioning

confidence: 97%

Section: Objective Assessmentmentioning

confidence: 99%

See 2 more Smart Citations

Sleep in Schizophrenia: Impairments, Correlates, and Treatment

Benson¹

2006

Psychiatric Clinics of North America

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“…Schizophrenia patients have been reported to commonly have sleep disturbances (Monti and Monti 2005;Trbovic 2010) including poor sleep efficiency, increased sleep onset latency (Tandon et al 1992), and decreased rapid eye movement sleep latency (Zarcone et al 1987). The cause of these sleep problems has yet to be elucidated; however, it has been suggested that these problems are associated with abnormalities in the neuroendocrine systems which regulate sleep and wakefulness and in particular, melatonin signaling (Monteleone et al 1997;Robinson et al 1991).…”

Section: Introductionmentioning

confidence: 99%

Association of Polymorphism in the Promoter of the Melatonin Receptor 1A Gene with Schizophrenia and with Insomnia Symptoms in Schizophrenia Patients

Park

Kim

et al. 2011

J Mol Neurosci

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Schizophrenia patients commonly have sleep disturbances. In this study, we investigated whether single nucleotide polymorphisms (SNPs) in the promoter region of the melatonin receptor genes (MTNR1A and MTNR1B) were associated with schizophrenia and with sleep problems such as insomnia and hypersomnia in schizophrenia patients. We genotyped two promoter SNPs [rs2119882 (-184T/C) of MTNR1A and rs4753426 (-1193C/T) of MTNR1B] using direct sequencing in 289 schizophrenia patients and 505 control subjects. We found that rs2119882 of MTNR1A was associated with schizophrenia in recessive model [CC vs. TT/TC, p = 0.013, odds ratio (OR) = 1.69, 95% confidence interval (CI) = 1.12-2.55]. Interestingly, in an analysis of clinical phenotypes, we found that rs2119882 of MTNR1A was also associated with insomnia symptoms of schizophrenia (recessive model, p = 0.010, OR = 2.24, 95% CI = 1.21-4.14), but not with hypersomnia symptoms as determined using the Operational Criteria checklist. However, rs4753426 of MTNR1B was not associated with either schizophrenia or clinical phenotypes. Our results suggest that MTNR1A may be a susceptibility gene for schizophrenia and may be associated with insomnia symptoms exhibited in schizophrenia patients.

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Neuropsychological function and REM sleep in schizophrenic patients

Taylor

Goldman

Tandon

et al. 1992

Biological Psychiatry

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To test the hypothesis that rapid eye movement (REM) sleep in schizophrenic patients is associated with cognitive function, we studied 18 schizophrenic inpatients by means of electroencephalograms taken during sleep in their own hospital beds after a minimum 2-wk medication withdrawal period. Patients underwent neuropsychological tests to measure memory function and other aspects of cognitive performance. REM sleep measures demonstrated positive and negative correlations with cognition and memory measures, depending on when REM occurred after sleep onset. Minutes of REM sleep and REM density in the first period correlated negatively with performance, while REM minutes occurring after the first REM period correlated positively with neuropsychological performance. Further work should test whether phasic REM sleep regulation at the beginning of the night plays a compensatory role for neuropsychological dysfunction in schizophrenics.

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Electroencephalographic sleep abnormalities in schizophrenia: Relationship to positive/negative symptoms and ventricular size

Cited by 15 publications

References 0 publications

Sleep in Schizophrenia: Impairments, Correlates, and Treatment

Sleep in Schizophrenia: Impairments, Correlates, and Treatment

Association of Polymorphism in the Promoter of the Melatonin Receptor 1A Gene with Schizophrenia and with Insomnia Symptoms in Schizophrenia Patients

Neuropsychological function and REM sleep in schizophrenic patients

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