Electroencephalographic Findings Related With Mild Cognitive Impairment in Idiopathic Rapid Eye Movement Sleep Behavior Disorder

Sasai, Taeko; Matsuura, Masato; Inoue, Yuichi

doi:10.5665/sleep.3224

Cited by 49 publications

(27 citation statements)

References 39 publications

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“…That study was the first to show impaired cortical activation during both wakefulness and REM sleep in iRBD although changes in sleep architecture were absent. The results were replicated by studies conducted in later years [25,35]. …”

Section: Quantitative and Qualitative Eeg Findings In Irbdsupporting

confidence: 77%

“…These findings strongly affected the relationship between cognitive decline and EEG slowing in patients with iRBD. In line with this report, our study also revealed that MCI determined using the Montreal cognitive assessment scale [47] was observed in more than 75% of the iRBD patients, and that age and log(θ power during REM sleep) was significantly associated with the this score in multiple regression analysis in this patients population [35]. In addition, a decrease in the score of the Sniffin' Stick test (threshold-discrimination-identification score), which is known as an early LBD marker [48], was significantly associated with the Montreal cognitive assessment score in this analysis.…”

Section: Relationship Between Eeg Slowing and Cognitive Impairment Insupporting

confidence: 73%

“…Therefore, a dysfunctioning cholinergic subcortical system might contribute to cognitive impairment and EEG slowing in iRBD patients. The fact that cholinergic activity promotes REM sleep, in which EEG slowing was observed in the studies described above [23,25,35], and that cholinergic denervation of the limbic cortex is a robust determinant of hyposmia [59], which was recognized in our study using threshold-discrimination-identification scores on Sniffin' Stick tests [35], might support this idea.…”

Section: Mechanism Of Eeg Slowing and Cognitive Decline In Irbdsupporting

confidence: 64%

“…The results demonstrated that iRBD patients exhibited significantly lower α and β power in the central and occipital regions during wakefulness and REM stage (but not during NREM sleep) than controls (fig. 3) [35]. Although clearly increased power in the low-frequency band was not seen in our patients, this finding raised the possibility of the existence of decreased cortical activation, even in this young iRBD patient population.…”

Section: Quantitative and Qualitative Eeg Findings In Irbdmentioning

confidence: 49%

“…To clarify this issue, we conducted a similar EEG power spectral analysis in younger iRBD patients (60.5 ± 5.3 years) and age-matched controls [35]. The results demonstrated that iRBD patients exhibited significantly lower α and β power in the central and occipital regions during wakefulness and REM stage (but not during NREM sleep) than controls (fig.…”

Section: Quantitative and Qualitative Eeg Findings In Irbdmentioning

confidence: 99%

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Electroencephalographic Finding in Idiopathic REM Sleep Behavior Disorder

2015

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The REM sleep behavior disorder (RBD) is a type of parasomnia manifested by vivid, often frightening dreams associated with motor behaviors during REM sleep, sometimes causing injuries to patients themselves or to their bed partners. The polysomnographic features of RBD include increased muscle activity during REM sleep (REM sleep without atonia). The majority of RBD-affected persons are older men. The disorder might be idiopathic (iRBD) or secondary to neurological disorders of various kinds. iRBD management with pharmaceutical measures is usually straightforward and effective. Several longitudinal studies have revealed that a high proportion of iRBD patients convert to α-synucleinopathies such as Parkinson's disease and dementia with Lewy body disease (DLB). Considering this, many studies have been conducted to identify common clinical markers between α-synucleinopathies and iRBD or indicators for the future development of α-synucleinopathies in iRBD patients. In this context, electroencephalographic (EEG) slowing occurring while awake and asleep, which is frequently observed in DLB, has received much attention. Clarification of the association between EEG slowing and the presence of mild cognitive impairment, which is also commonly seen in early stages of DLB, has been particularly expected to offer a breakthrough for the identification of cases which might convert to α-synucleinopathies. In this article, we introduce the progress in quantitative EEG research in iRBD during the past decade. We also discuss the relationship between EEG findings and cognitive decline as well as the mechanisms of EEG changes or cognitive abnormalities in patients with the disorder.

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Section: Quantitative and Qualitative Eeg Findings In Irbdsupporting

confidence: 77%

Section: Relationship Between Eeg Slowing and Cognitive Impairment Insupporting

confidence: 73%

Section: Mechanism Of Eeg Slowing and Cognitive Decline In Irbdsupporting

confidence: 64%

Section: Quantitative and Qualitative Eeg Findings In Irbdmentioning

confidence: 49%

Section: Quantitative and Qualitative Eeg Findings In Irbdmentioning

confidence: 99%

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Electroencephalographic Finding in Idiopathic REM Sleep Behavior Disorder

2015

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Rapid Eye Movement Sleep Behavior Disorder and Neurodegenerative Disease

2015

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Polysomnographic and neuropsychological characteristics of rapid eye movement sleep behavior disorder patients

Zhang

Song

et al. 2019

Brain and Behavior

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Objectives To compare the sleep characteristics and cognition between rapid eye movement sleep behavior disorder (RBD) patients and non‐RBD (nRBD) healthy control subjects and to determine the correlation between sleep and cognition in RBD patients. Methods Polysomnography (PSG) was performed to confirm and exclude RBD. Fifteen iRBD patients, 12 PD with RBD patients, and 23 matched nRBD healthy control subjects were enrolled. Subjective sleep and neuropsychological evaluations were performed. Results No differences were found in the subjective sleep among the three groups. Compared to the nRBD subjects, iRBD patients showed higher PLMI, the PD with RBD patients showed an increased proportion of N1 sleep, a decreased proportion of N2 and N3 sleep, and an increased periodic leg movement index. The iRBD patients performed worse on RCFT time than the nRBD subjects, the PD with RBD patients performed worse than the nRBD subjects on the following evaluations: the Mini‐Mental State Examination; auditory verbal learning test (AVLT); Rey Complex Figure Test (RCFT) time, Clock drawing test (CDT); delay memory score of RCFT; Symbol digit modalities test (SDMT); Trail Making Test (TMT); and Stroop Test B and C, all significant changes (all p < 0.05). Furthermore, in RBD patients, lower sleep efficiency was correlated with decreased SDMT scores ( r = 0.694, p < 0.01), longer time on the TMT A ( r = −0.589, p < 0.01), and lower city fluency test scores( r = 0.556, p < 0.01). Less total sleep time was correlated with lower RCFT scores ( r = 0.392, p = 0.043), longer time on the TMT A ( r = −0.417, p = 0.031), and lower city fluency test scores ( r = 0.405, p = 0.036). Conclusions PD with RBD patients suffered from abnormal sleep architecture and extensive cognition dysfunction. Decreased total sleep time and sleep efficiency may contribute to cognitive deterioration in RBD patients.

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Electroencephalographic Findings Related With Mild Cognitive Impairment in Idiopathic Rapid Eye Movement Sleep Behavior Disorder

Abstract: Electroencephalographic slowing, especially during rapid eye movement sleep and olfactory dysfunction, was revealed to be associated with cognitive decline in idiopathic rapid eye movement sleep behavior disorder.

Cited by 49 publications

References 39 publications

Electroencephalographic Finding in Idiopathic REM Sleep Behavior Disorder

Electroencephalographic Finding in Idiopathic REM Sleep Behavior Disorder

Rapid Eye Movement Sleep Behavior Disorder and Neurodegenerative Disease

Polysomnographic and neuropsychological characteristics of rapid eye movement sleep behavior disorder patients

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