Electroencephalographic correlates of electroconvulsive therapy

Kolbeinsson, H.; Pétursson, Hannes

doi:10.1111/j.1600-0447.1988.tb06316.x

Cited by 12 publications

(8 citation statements)

References 9 publications

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“…Among the most methodologically sound studies published after Weiner’s (24) review, Kolbeinsson and Petursson (25) submitted 17 depressed patients to a mean of 6.8 unilateral ECT treatments. At baseline a subgroup of nine patients who had previously received ECT (a mean of 26 months ago) was observed to have an elevated slow-wave activity as compared to the ECT naive.…”

Section: Frontotemporal Effectsmentioning

confidence: 99%

Electroconvulsive Treatment: Hypotheses about Mechanisms of Action

Fosse¹,

Read²

2013

Front. Psychiatry

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No consensus has been reached on the mode of action of electroconvulsive treatment (ECT). We suggest that two features may aid in the delineation of the involved mechanisms. First, when effective, ECT would be likely to affect brain functions that are typically altered in its primary recipient group, people with severe depression. Central among these are the frontal and temporal lobes, the hypothalamus-pituitary-adrenal (HPA) stress axis, and the mesocorticolimbic dopamine system. Second, the involved mechanisms should be affected for a time period that matches the average endurance of clinical effects, which is indicated to be several days to a few weeks. To identify effects upon frontal and temporal lobe functioning we reviewed human studies using EEG, PET, SPECT, and fMRI. Effects upon the HPA axis and the dopamine system were assessed by reviewing both human and animal studies. The EEG studies indicate that ECT decelerates neural activity in the frontal and temporal lobes (increased delta and theta wave activity) for weeks to months. Comparable findings are reported from PET and SPECT studies, with reduced cerebral blood flow (functional deactivation) for weeks to months after treatment. The EEG deceleration and functional deactivation following ECT are statistically associated with reduced depression scores. FMRI studies indicate that ECT flattens the pattern of activation and deactivation that is associated with cognitive task performance and alters cortical functional connectivity in the ultra slow frequency range. A common finding from human and animal studies is that ECT acutely activates both the HPA axis and the dopamine system. In considering this evidence, we hypothesize that ECT affects the brain in a similar manner as severe stress or brain trauma which activates the HPA axis and the dopamine system and may compromise frontotemporal functions.

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Section: Frontotemporal Effectsmentioning

confidence: 99%

Electroconvulsive Treatment: Hypotheses about Mechanisms of Action

Fosse¹,

Read²

2013

Front. Psychiatry

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“…Following our previous work on ECT side-effects our interest in the subject is partly theoretical, hoping to extend the current level of understanding of the cognitive sideeffects of ECT and mood disturbances (5, 16,17). Furthermore, the results have forensic implications, extending the work already done by Gudjonsson and co-workers on suggestibility and confabulation (12).…”

mentioning

confidence: 90%

“…The ECT treatment took place during the 4-week period between the second and third memory tests in the fxst phase (delayed recall 1 and 2, respectively). The details of ECT administration at the ward have been presented elsewhere (16). Six patients received bilateral ECT on all or some occasions, and 9 received solely unilateral ECT.…”

Section: Effects Of Mood and Ect In Confabulation 445mentioning

confidence: 99%

The effects of electroconvulsive therapy and depression on confabulation, memory processing, and suggestibility

Sigurðsson

Gudjónsson

Kolbeinsson

et al. 1994

Nordic Journal of Psychiatry

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effects of electroconvulsive therapy and depression on confabulation, memory processing, and suggestibility. Nord J Psychiatry 1994;48:443451. Oslo. ISSN 0803-9488.A prospective study was carried out to investigate the influence of electroconvulsive therapy (ECT) and depression on confabulation, verbal memory, and suggestibility. The subjects were 30 depressed patients with major depressive disorder as defined by DSM-III-R criteria, half of whom were treated with ECT, the other half with antidepressants only, and a control group of I5 healthy subjects. All participants were assessed with the Gudjonsson Suggestibility Scales (GSS), which measured confabulation, memory, and suggestibility. The patients were also assessed with the Hamilton Rating Scale for Depression (HRSD). Contrary to predictions, confabulation was significantly higher among the controls than patients during inpatient treatment, ECT-treated patients catching up with controls during convalescence. ECT but not depression had a significant effect on delayed recall at the end of the inpatient period. Neither ECT nor depression significantly affected suggestibility. A significant negative correlation was noted between age and confabulation.

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“…Electrophysiological data were collected under standard conditions, including recording of the computerized EEG, auditory evoked potential (AEP), SCL and ST. The electrophysiological data were collected by use of an on-line laboratory computer (Biodata Cean 400 Physiological Data Analysis System), the method being identical to the procedure used in our laboratory (29).…”

Section: Methodsmentioning

confidence: 99%

Dementia and depression in old age: psychophysiological aspects

Have¹,

Kolbeinsson²,

Pétursson³

1991

Acta Psychiatr Scand

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This study describes the psychophysiological results of a larger investigation of the clinical, morphological, psychometric and psychophysiological aspects of dementia of the Alzheimer type and depression in elderly patients. Healthy volunteers provided a further measure of control. It was found that widely used clinical rating scales delineated the 3 groups of subjects to a significant degree. The average frequency of the electroencephalogram (EEG), the P2-N2 peak-to-peak amplitude and P3 latency of the auditory evoked potential and a characteristic downward shift of the EEG power spectrum differed significantly between demented patients, depressive patients and normal controls. The higher total power in the EEG of the dementia group did not prove statistically significant, probably because of the small numbers. Other psychophysiological measures such as skin conductance level (SCL) and skin temperature (ST) did not reveal statistically significant differences between the groups. Thus, certain psychophysiological measurements may become valuable in the differential diagnosis of these disorders.

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Electroencephalographic correlates of electroconvulsive therapy

Cited by 12 publications

References 9 publications

Electroconvulsive Treatment: Hypotheses about Mechanisms of Action

Electroconvulsive Treatment: Hypotheses about Mechanisms of Action

The effects of electroconvulsive therapy and depression on confabulation, memory processing, and suggestibility

Dementia and depression in old age: psychophysiological aspects

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