Electroencephalographic correlates of Chronic Fatigue Syndrome

Decker, Michael J.; Tabassum, Humyra; Lin, Jin Mann S.; Reeves, William C.

doi:10.1186/1744-9081-5-43

Cited by 32 publications

(40 citation statements)

References 35 publications

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“…Decker reported differences in delta power, with reduced delta power observed in SWS and increased delta power during stage 1 and REM sleep in 35 CFS/ME patients relative to 40 healthy controls. 52 Reductions in alpha power were observed most strongly during REM but were also seen in SWS and stage 2 in the CFS/ ME subjects. The finding of attenuated delta power complements the reduced SWA reported previously following sleep delay, 49 providing further evidence of an altered sleep homeostat in CFS/ME.…”

Section: Microstructure Measures Of Sleep In Cfs/mementioning

confidence: 87%

“…Power spectral analysis using fast Fourier transform (FFT) has been used in a few recent studies, 51,52 with conflicting results. Decker reported differences in delta power, with reduced delta power observed in SWS and increased delta power during stage 1 and REM sleep in 35 CFS/ME patients relative to 40 healthy controls.…”

Section: Microstructure Measures Of Sleep In Cfs/mementioning

confidence: 99%

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Sleep Abnormalities in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Review

Jackson

Bruck

2012

Journal of Clinical Sleep Medicine

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Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ ME) is a chronic, disabling illness that affects approximately 0.2% of the population. Non-restorative sleep despite sufficient or extended total sleep time is one of the major clinical diagnostic criteria; however, the underlying cause of this symptom is unknown. This review aims to provide a comprehensive overview of the literature examining sleep in CFS/ ME and the issues surrounding the current research fi ndings. Polysomnographic and other objective measures of sleep have observed few differences in sleep parameters between CFS/ME patients and healthy controls, although some discrepancies do exist. This lack of signifi cant objective differences contrasts with the common subjective complaints of disturbed and unrefreshed sleep by CFS/ME patients. The emergence of new, more sensitive techniques that examine the microstructure of sleep are showing promise for detecting differences in sleep between patients and healthy individuals. There is preliminary evidence that alterations in sleep stage transitions and sleep instability, and other physiological mechanisms, such as heart rate variability and altered cortisol profi les, may be evident. Future research investigating the etiology of non-restorative sleep in CFS/ME may also help us to undercover the causes of non-restorative sleep and fatigue in other medical conditions. keywords: Chronic fatigue syndrome, myalgic encephalomyelitis, sleep, non-restorative sleep, sleep disorders, fatigue, sleepiness Citation: Jackson ML; Bruck D. Sleep abnormalities in chronic fatigue syndrome/myalgic encephalomyelitis: a review.

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Section: Microstructure Measures Of Sleep In Cfs/mementioning

confidence: 87%

Section: Microstructure Measures Of Sleep In Cfs/mementioning

confidence: 99%

Sleep Abnormalities in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Review

Jackson

Bruck

2012

Journal of Clinical Sleep Medicine

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“…Delta power was observed to be slightly elevated overall in the CFS twins, but not enough to significantly differentiate them from their healthy co-twins. [57] Decker and colleagues [46] also used FFT to analyse the PSG recordings of 35 CFS patients (Wichita population study) in comparison to 40 non-fatigued controls. Overall there was significantly reduced spectral power of alpha activity in CFS subjects during N2 sleep with the greatest reduction observed during REM sleep.…”

Section: Sleep Stage Activitymentioning

confidence: 99%

“…PSG studies have largely been conducted over one night [24,26,27,30,33,[40][41][42][43][44] or two, [34,36,37,[45][46][47][48][49][50][51][52] which may generate a "first-night effect." The continuity and architectural findings of these studies are discussed in the following section.…”

Section: Polysomnography (Psg) Studiesmentioning

confidence: 99%

The role of sleep in chronic fatigue syndrome: a narrative review

Gotts

Ellis

Newton

et al. 2014

Fatigue: Biomedicine, Health & Behavior

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Background: Chronic Fatigue Syndrome (CFS) affects 0.23-2.6% of the adult population. Sleep-related complaints are amongst the most frequently reported symptoms in these patients. Although a biopsychosocial model of CFS offers a plausible framework for understanding the condition, the role of sleep and how it functions within this model remains unclear. Purpose: This narrative review describes the findings of studies of sleep in CFS and considers the reasons behind the diversity of results. The review also discusses the difficulties that exist in establishing relationships between sleep, behaviour, cognition, physiology, and the physical symptoms of CFS. Methods: A search of Medline for the terms "CFS," "chronic fatigue syndrome," AND "sleep" was performed to identify articles concerning sleep and CFS from 1988 to the present. Results: Subjective sleep dysfunction was frequently reported in the CFS sleep studies. However, objective sleep research in CFS has shown no consistent picture of sleep disturbance, particularly with regard to polysomnography. This may be attributable to the heterogeneity of sleep phenotypes in the CFS population as well as the variability in sleep assessment protocols, case definitions, and exclusion criteria used across studies. Conclusions: Given the high prevalence of disturbed sleep in this population in combination with inconsistent findings, exploration of new protocols for the objective assessment of sleep in CFS (e.g., three-night PSG protocol) is recommended. Understanding the distinct sleep characteristics in this population could serve to improve insight into perpetuating factors of CFS symptoms which is relevant for diagnosis and therapy.

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“…27, 28 In the latter study, findings were used to distinguish patients with CFS from healthy controls with 80% accuracy. 28 Given the strong links of neurofunctional measures to CFS symptomatology, these measures are a promising means of characterizing a subset of patients with CFS whose pathophysiology may relate to neurological dysfunction.…”

Section: Neurological Biomarkers Of Cfs (Table 1)mentioning

confidence: 99%

Chronic fatigue syndrome: the current status and future potentials of emerging biomarkers

Fischer

William

Strauss

et al. 2014

Fatigue: Biomedicine, Health & Behavior

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Chronic fatigue syndrome (CFS) remains an incompletely characterized illness, in part due to controversy regarding its definition, biological basis and diagnosis. Biomarkers are objective measures that may lead to improvements in our understanding of CFS by providing a more coherent and consistent approach to study, diagnosis and treatment of the illness. Such metrics may allow us to distinguish between CFS subtypes – each defined by characteristic biomarkers – currently conflated under the single, heterogeneous condition of CFS. These delineations, in turn, may guide more granular, focused, and targeted treatment strategies based on more precise characterizations of the illness. Here, we review potential CFS biomarkers related to neurological and immunological components of the illness, and discuss how these biomarkers may be used to move the field of CFS forward, emphasizing clinical utility and potential routes of future research.

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Electroencephalographic correlates of Chronic Fatigue Syndrome

Cited by 32 publications

References 35 publications

Sleep Abnormalities in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Review

Sleep Abnormalities in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Review

The role of sleep in chronic fatigue syndrome: a narrative review

Chronic fatigue syndrome: the current status and future potentials of emerging biomarkers

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