Electroencephalographic Changes During Brief Cardiac Arrest in Humans

Clute, Holly L.; Levy, Warren J.

doi:10.1097/00000542-199011000-00004

Cited by 91 publications

(43 citation statements)

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“…However, probably due to the complexity of electrode placement and interpretation, there have been very few case reports [3,4] or human studies [5] on the relationship between EEG and the state of cerebral perfusion in anaesthetised patients. BIS, derived from multivariate analysis of rolling .............................................................................................................................................................................................................. [6], decreases in its value during hypotension or cardiac arrest [1,7], analogous to the EEG changes above, have been reported.…”

Section: Discussionmentioning

confidence: 99%

The use of bispectral index during a cardiopulmonary arrest: a potential predictor of cerebral perfusion

Azim

Wang

2004

Anaesthesia

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SummaryA 62-year-old male underwent off-pump coronary artery grafting surgery while cerebral function was monitored with bispectral index (BIS). The BIS monitoring was continued into the immediate postoperative period, during which time the patient experienced a cardiopulmonary arrest. The changes in the BIS values helped the resuscitating team in assessing the cerebral response to the cardiopulmonary resuscitation.

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Section: Discussionmentioning

confidence: 99%

The use of bispectral index during a cardiopulmonary arrest: a potential predictor of cerebral perfusion

Azim

Wang

2004

Anaesthesia

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“…[5][6][7][8][9] More recently, Dworshak et al 10 measured the cytoplasmic enzymes neuron-specific enolase (NSE) and S100 leaked from brain cells in the early course of cerebral ischemia in 45 ICD recipients. Levels were taken before surgery and 2 hours after surgery.…”

Section: Editorial See Page 118 Clinical Perspective On P 177mentioning

confidence: 99%

A Prospective 1-Year Study of Changes in Neuropsychological Functioning After Implantable Cardioverter-Defibrillator Surgery

Hallas

Burke²,

White³

et al. 2010

Circ: Arrhythmia and Electrophysiology

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Background-The testing of the implantable cardioverter-defibrillator (ICD), through the induction of repeated episodes of ventricular fibrillation, has been associated with disturbances in cerebral activity and increased levels of cytoplasmic enzymes. However, the neuropsychological outcomes of cerebral changes and their quality-of-life implications are unknown. Methods and Results-Fifty-two ICD recipients completed standardized validated neuropsychological tests 1 to 3 days before ICD surgery and then 6 weeks, 6 months, and 12 months after surgery. They also completed psychometric tests measuring anxiety, depression, and quality of life. Between 31% and 39% of patients showed a significant neuropsychological impairment from their baseline function 6 weeks, 6 months, and 12 months after surgery. Ten percent of patients had late-onset deficits at 12 months only. Frequent areas of impairment were auditory and visual memory and attention. Neuropsychological impairment was not related to mood or quality of life at follow-up, although anxiety and depression predicted reduced quality of life. Conclusions-ICD implantation is associated with neuropsychological impairment that dissipates for the majority of recipients after 12 months. Short-term memory function and attention are particularly vulnerable to changes in oxygen during ICD testing. Although anxiety and depression are prevalent, there is little evidence for the direct impact of mood on cognition, and deficits appear not to be associated with reduced quality of life. These results provide evidence for longitudinal outcomes of ICD surgery and have implications for patient rehabilitation and adjustment. (Circ Arrhythm Electrophysiol. 2010;3:170-177.)

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“…40% of the basal value; after releasing the clamps that value reverted to the pre-ischemic level and remained at that level until 4 days after 2VO. The EEG data show that delta wave activities increased, whereas those of alpha and beta waves decreased during occlusion, which might reflect cerebral ischemic changes resulting from carotid artery occlusion (23,24). The EEG profiles inversely changed just after reperfusion: that is, the activities of delta waves decreased and those of beta waves increased, which caused the reversion to the pre-ischemic profiles by 4 days after 2VO.…”

Section: Discussionmentioning

confidence: 87%

Therapeutic Potentials of an Artificial Oxygen-Carrier, Liposome-Encapsulated Hemoglobin, for Ischemia/Reperfusion-Induced Cerebral Dysfunction in Rats

et al. 2010

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Abstract. We performed this study to elucidate whether a newly developed liposome-encapsulated hemoglobin, TRM-645 (TRM), can prevent cerebral dysfunction resulting from acute ischemic stroke when used as an oxygen carrier. Hippocampal long-term potentiation (LTP) in the perforant path-dentate gyrus synapses and anxiety-related behaviors in the elevated plus-maze test were evaluated as indices of cerebral functional outcomes in the rat with two-vessel occlusion (2VO), which was induced by 10-min clamping of bilateral common carotid arteries. Saline or TRM (hemoglobin concentration of 6 g/dl: 2.5 or 5 ml/kg) was administered via the tail vein immediately after ischemic insult. Hippocampal LTP formation was markedly impaired and the open arm durations in the elevated plus-maze decreased significantly 4 days after 2VO, compared to those of sham-operated (control) rats, suggesting the hippocampal synaptic dysfunction and anxiogenic properties in 2VO rats. TRM (5 ml/kg) restored the hippocampal LTP formation and normalized the anxiety-related behavior. TRM also improved the decreased tissue oxygen partial pressure in the 2VO rat hippocampus, possibly due to oxygen delivery to ischemic regions. Liposomeencapsulated hemoglobin TRM might have therapeutic potentials for protecting the brain from neurological complications associated with acute ischemic stroke, as a promising blood substitute for oxygen therapy.

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Electroencephalographic Changes During Brief Cardiac Arrest in Humans

Cited by 91 publications

References 0 publications

The use of bispectral index during a cardiopulmonary arrest: a potential predictor of cerebral perfusion

The use of bispectral index during a cardiopulmonary arrest: a potential predictor of cerebral perfusion

A Prospective 1-Year Study of Changes in Neuropsychological Functioning After Implantable Cardioverter-Defibrillator Surgery

Therapeutic Potentials of an Artificial Oxygen-Carrier, Liposome-Encapsulated Hemoglobin, for Ischemia/Reperfusion-Induced Cerebral Dysfunction in Rats

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